Bupropion: study card

Bupropion — Aminoketone antidepressant (NDRI). Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Bupropion
Class
Aminoketone antidepressant (NDRI)
Mechanism
Relatively weak inhibitor of neuronal norepinephrine and dopamine reuptake; does not inhibit serotonin reuptake or monoamine oxidase.
Used for
Major depressive disorder in adults
Common side effects
Headache; Dry mouth; Nausea; Insomnia; Dizziness
Boxed warning
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents and young adults.
Warnings
Seizure risk (dose-related); Neuropsychiatric events in smoking cessation; Hypertension
Interactions
CYP2B6 inducers; CYP2D6 substrates (e.g. metoprolol); MAOIs

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260827 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Bupropion: byoo-PROE-pee-on

Pronunciation is shown for the US English generic name.

Body system

Psychiatry · 30 Drug cards

Compare with related cards

Duloxetine

Same body system: Psychiatry

Mechanism: Exact mechanism unknown; believed to potentiate serotonergic and noradrenergic activity in the CNS.

On both cards: Used for — Major depressive disorder in adults · Common side effects — Dry mouth; Nausea · Interactions — MAOIs

Only on the Duloxetine card: Used for — Generalized anxiety disorder in adults and children aged 7 years and older; Diabetic peripheral neuropathic pain in adults; Fibromyalgia in adults and adolescents aged 13 years and older; Chronic musculoskeletal pain in adults · Common side effects — Somnolence; Constipation; Hyperhidrosis · Warnings — Hepatotoxicity; Orthostatic hypotension, falls, syncope; Serotonin syndrome · Interactions — Potent CYP1A2 inhibitors; Potent CYP2D6 inhibitors

Fluoxetine

Same body system: Psychiatry

Mechanism: Exact mechanism unknown; presumed linked to inhibition of CNS neuronal uptake of serotonin.

On both cards: Common side effects — Nausea; Insomnia · Interactions — MAOIs

Only on the Fluoxetine card: Used for — Major depressive disorder in adults and children aged 8 years and older; Obsessive-compulsive disorder in adults and children aged 7 years and older; Binge-eating and vomiting in adults with moderate to severe bulimia nervosa; Panic disorder in adults · Common side effects — Anxiety; Somnolence; Diarrhea · Warnings — Serotonin syndrome; Allergic reactions and rash; Suicidal thoughts in young patients · Interactions — CYP2D6 substrates (potent CYP2D6 inhibitor); Tricyclic antidepressants

Buspirone

Same body system: Psychiatry

Mechanism: Mechanism is unknown. Preclinical studies show high 5-HT1A receptor affinity; buspirone also has moderate D2 affinity, no significant benzodiazepine-receptor affinity and no effect on GABA binding in the tested preclinical models.

On both cards: Common side effects — Headache; Nausea; Dizziness

Only on the Buspirone card: Used for — Anxiety disorders; Short-term relief of anxiety symptoms · Common side effects — Nervousness; Lightheadedness · Warnings — Contraindicated with MAOIs (serotonin syndrome); Hypersensitivity to buspirone · Interactions — MAO inhibitors; Linezolid / IV methylene blue; CYP3A4 inhibitors and inducers

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Other cards with a boxed warning in this body system (Psychiatry): Sertraline, Escitalopram, Fluoxetine, Trazodone, Amphetamine / Dextroamphetamine, Duloxetine, Alprazolam, Citalopram, Venlafaxine, Zolpidem, Methylphenidate, Lorazepam (+14)