MAO inhibitors; Other serotonergic drugs; Antiplatelets / anticoagulants
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260827 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Exact mechanism unknown; believed to potentiate serotonergic and noradrenergic activity in the CNS.
On both cards: Used for — Major depressive disorder in adults · Common side effects — Nausea; Somnolence; Dry mouth · Warnings — Serotonin syndrome
Only on the Duloxetine card: Used for — Generalized anxiety disorder in adults and children aged 7 years and older; Diabetic peripheral neuropathic pain in adults; Fibromyalgia in adults and adolescents aged 13 years and older; Chronic musculoskeletal pain in adults · Common side effects — Constipation; Hyperhidrosis · Warnings — Hepatotoxicity; Orthostatic hypotension, falls, syncope · Interactions — Potent CYP1A2 inhibitors; Potent CYP2D6 inhibitors; MAOIs
Mechanism: Thought to potentiate serotonin and norepinephrine in the CNS by inhibiting their reuptake; a potent, selective SNRI.
On both cards: Common side effects — Nausea · Warnings — Serotonin syndrome; Elevated blood pressure · Interactions — Other serotonergic drugs
Only on the Desvenlafaxine card: Used for — Major depressive disorder (adults) · Common side effects — Dizziness; Insomnia; Hyperhidrosis; Constipation · Warnings — Increased bleeding risk · Interactions — MAO inhibitors (contraindicated); Aspirin, NSAIDs, anticoagulants
Mechanism: Presumed to potentiate CNS serotonergic activity by inhibiting neuronal reuptake of serotonin (5-HT).
On both cards: Used for — Major depressive disorder in adults · Common side effects — Nausea; Somnolence; Dry mouth; Sweating; Abnormal ejaculation · Warnings — Serotonin syndrome
Only on the Paroxetine card: Used for — Obsessive-compulsive disorder and panic disorder in adults; Social anxiety disorder and generalized anxiety disorder in adults; Posttraumatic stress disorder in adults · Warnings — Embryofetal toxicity; Increased risk of bleeding · Interactions — MAOIs (contraindicated); Thioridazine / pimozide (contraindicated); Anticoagulants / NSAIDs
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Boxed warnings on related cards
Duloxetine: Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents and young adults.
Desvenlafaxine: Antidepressants increased suicidal thoughts and behaviors in children, adolescents, and young adults; monitor closely for worsening.
Capsera