Fluoxetine: study card

Fluoxetine — Selective serotonin reuptake inhibitor (SSRI). Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Fluoxetine
Class
Selective serotonin reuptake inhibitor (SSRI)
Mechanism
Exact mechanism unknown; presumed linked to inhibition of CNS neuronal uptake of serotonin.
Used for
Major depressive disorder in adults and children aged 8 years and older; Obsessive-compulsive disorder in adults and children aged 7 years and older; Binge-eating and vomiting in adults with moderate to severe bulimia nervosa; Panic disorder in adults
Common side effects
Nausea; Insomnia; Anxiety; Somnolence; Diarrhea
Boxed warning
Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents and young adults.
Warnings
Serotonin syndrome; Allergic reactions and rash; Suicidal thoughts in young patients
Interactions
MAOIs; CYP2D6 substrates (potent CYP2D6 inhibitor); Tricyclic antidepressants

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Drug class families: Selective serotonin reuptake inhibitors

Read the source label ↗

Label date: 20260820 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Fluoxetine: floo-OX-e-teen

Pronunciation is shown for the US English generic name.

Other drugs in the same class

Selective serotonin reuptake inhibitors: Citalopram, Paroxetine, Sertraline, Escitalopram

Body system

Psychiatry · 30 Drug cards

Compare with related cards

Escitalopram

Same class family: Selective serotonin reuptake inhibitors

Mechanism: The S-enantiomer of citalopram inhibits neuronal serotonin reuptake. Its antidepressant action is presumed to relate to increased serotonergic activity in the CNS.

On both cards: Common side effects — Nausea; Insomnia · Warnings — Serotonin syndrome

Only on the Escitalopram card: Used for — Major depressive disorder in adults and children aged 12 years and older; Generalized anxiety disorder in adults · Common side effects — Ejaculation disorder; Increased sweating; Fatigue, somnolence · Warnings — Hyponatremia; Increased risk of bleeding · Interactions — MAOIs (incl. linezolid, IV methylene blue); Pimozide; NSAIDs, aspirin, warfarin

Paroxetine

Same class family: Selective serotonin reuptake inhibitors

Mechanism: Presumed to potentiate CNS serotonergic activity by inhibiting neuronal reuptake of serotonin (5-HT).

On both cards: Common side effects — Nausea; Somnolence · Warnings — Serotonin syndrome

Only on the Paroxetine card: Used for — Major depressive disorder in adults; Obsessive-compulsive disorder and panic disorder in adults; Social anxiety disorder and generalized anxiety disorder in adults; Posttraumatic stress disorder in adults · Common side effects — Abnormal ejaculation; Dry mouth; Sweating · Warnings — Embryofetal toxicity; Increased risk of bleeding · Interactions — MAOIs (contraindicated); Thioridazine / pimozide (contraindicated); Anticoagulants / NSAIDs

Sertraline

Same class family: Selective serotonin reuptake inhibitors

Mechanism: Potentiates serotonergic activity in the CNS by inhibiting neuronal reuptake of serotonin (5-HT).

On both cards: Common side effects — Nausea · Warnings — Serotonin syndrome

Only on the Sertraline card: Used for — Major depressive disorder in adults; Obsessive-compulsive disorder in adults and children aged 6–17 years; Panic disorder, PTSD or social anxiety disorder in adults; Premenstrual dysphoric disorder in adults · Common side effects — Diarrhea / loose stool; Tremor; Hyperhidrosis; Ejaculation failure · Warnings — Increased risk of bleeding; Activation of mania / hypomania · Interactions — MAOIs (incl. linezolid, IV methylene blue); Pimozide; Warfarin and other protein-bound drugs

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Sertraline: Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients.

Escitalopram: Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients.

Citalopram: Antidepressants increased suicidal thoughts and behaviors in pediatric and young adult patients; not approved in children.

Paroxetine: Antidepressants increased suicidal thoughts and behaviors in pediatric and young adult patients.