Trazodone — Serotonin antagonist and reuptake inhibitor (SARI). Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Trazodone
Class
Serotonin antagonist and reuptake inhibitor (SARI)
Mechanism
Inhibits serotonin reuptake and antagonizes 5HT2 receptors. Its antidepressant mechanism is not fully understood; enhancement of CNS serotonergic activity is a proposed explanation.
MAOIs; CNS depressants incl. alcohol; CYP3A4 inhibitors and inducers
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260827 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Exact mechanism unknown; believed to potentiate serotonergic and noradrenergic activity in the CNS.
On both cards: Used for — Major depressive disorder in adults · Warnings — Serotonin syndrome · Interactions — MAOIs
Only on the Duloxetine card: Used for — Generalized anxiety disorder in adults and children aged 7 years and older; Diabetic peripheral neuropathic pain in adults; Fibromyalgia in adults and adolescents aged 13 years and older; Chronic musculoskeletal pain in adults · Common side effects — Nausea; Dry mouth; Somnolence; Constipation; Hyperhidrosis · Warnings — Hepatotoxicity; Orthostatic hypotension, falls, syncope · Interactions — Potent CYP1A2 inhibitors; Potent CYP2D6 inhibitors
Mechanism: Potentiates serotonergic activity in the CNS by inhibiting neuronal reuptake of serotonin (5-HT).
On both cards: Used for — Major depressive disorder in adults · Warnings — Serotonin syndrome
Only on the Sertraline card: Used for — Obsessive-compulsive disorder in adults and children aged 6–17 years; Panic disorder, PTSD or social anxiety disorder in adults; Premenstrual dysphoric disorder in adults · Common side effects — Nausea; Diarrhea / loose stool; Tremor; Hyperhidrosis; Ejaculation failure · Warnings — Increased risk of bleeding; Activation of mania / hypomania · Interactions — MAOIs (incl. linezolid, IV methylene blue); Pimozide; Warfarin and other protein-bound drugs
Mechanism: Relatively weak inhibitor of neuronal norepinephrine and dopamine reuptake; does not inhibit serotonin reuptake or monoamine oxidase.
On both cards: Used for — Major depressive disorder in adults · Interactions — MAOIs
Only on the Bupropion card: Common side effects — Headache; Dry mouth; Nausea; Insomnia; Dizziness · Warnings — Seizure risk (dose-related); Neuropsychiatric events in smoking cessation; Hypertension · Interactions — CYP2B6 inducers; CYP2D6 substrates (e.g. metoprolol)
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Capsera