Methylphenidate: study card

Methylphenidate — CNS stimulant. Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Methylphenidate
Class
CNS stimulant
Mechanism
Blocks reuptake of norepinephrine and dopamine into presynaptic neurons and increases their release; therapeutic mode in ADHD unknown.
Used for
ADHD (ages 6 to 65)
Common side effects
Decreased appetite; Headache; Insomnia; Dry mouth; Upper abdominal pain (pediatric)
Boxed warning
High potential for abuse and misuse, which can lead to substance use disorder, addiction, overdose and death.
Warnings
Serious cardiac disease; increased BP and heart rate; Psychiatric reactions (mania, psychosis); Pediatric growth suppression; priapism
Interactions
MAO inhibitors (hypertensive crisis); Antihypertensive drugs; Halogenated anesthetics

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260827 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Methylphenidate: meth-il-FEN-i-date

Pronunciation is shown for the US English generic name.

Body system

Psychiatry · 30 Drug cards

Compare with related cards

Dexmethylphenidate

Same class on both cards

Mechanism: CNS stimulant; the mode of therapeutic action in ADHD is not known.

On both cards: Common side effects — Decreased appetite; Headache; Dry mouth · Interactions — Antihypertensive drugs

Only on the Dexmethylphenidate card: Used for — ADHD, for the cited extended-release capsules; not recommended below age 6 · Common side effects — Dyspepsia; Anxiety · Warnings — Serious cardiac disease; raised BP and heart rate; Psychiatric reactions (psychosis, mania); Priapism and peripheral vasculopathy · Interactions — MAOIs (hypertensive crisis)

Bupropion

Same body system: Psychiatry

Mechanism: Relatively weak inhibitor of neuronal norepinephrine and dopamine reuptake; does not inhibit serotonin reuptake or monoamine oxidase.

On both cards: Common side effects — Headache; Insomnia; Dry mouth

Only on the Bupropion card: Used for — Major depressive disorder in adults · Common side effects — Nausea; Dizziness · Warnings — Seizure risk (dose-related); Neuropsychiatric events in smoking cessation; Hypertension · Interactions — CYP2B6 inducers; CYP2D6 substrates (e.g. metoprolol); MAOIs

Lisdexamfetamine

Same body system: Psychiatry

Mechanism: Prodrug of dextroamphetamine, a non-catecholamine sympathomimetic amine with CNS stimulant activity.

On both cards: Common side effects — Decreased appetite; Insomnia; Dry mouth

Only on the Lisdexamfetamine card: Used for — ADHD in adults and children aged 6 or older; Moderate-to-severe binge-eating disorder in adults · Common side effects — Irritability; Upper abdominal pain · Warnings — Serious cardiac disease; Increased blood pressure and heart rate; Growth suppression in children; Not indicated for weight loss; safety and effectiveness for obesity have not been established · Interactions — MAOIs (contraindicated); Urinary acidifying / alkalinizing agents

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Dexmethylphenidate: High potential for abuse and misuse, which can lead to substance use disorder, overdose and death.