Naproxen — Nonsteroidal anti-inflammatory drug (NSAID). Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Naproxen
Class
Nonsteroidal anti-inflammatory drug (NSAID)
Mechanism
Has analgesic, anti-inflammatory and antipyretic effects. The mechanism is not completely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin production may contribute.
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260820 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Has analgesic, anti-inflammatory and antipyretic effects; its mechanism is believed to involve reduced prostaglandin synthesis, primarily through COX-2 inhibition.
On both cards: Used for — Primary dysmenorrhea · Common side effects — Dyspepsia; Abdominal pain · Interactions — Anticoagulants / antiplatelets; SSRIs / SNRIs (bleeding)
Only on the Celecoxib card: Used for — Signs and symptoms of osteoarthritis or rheumatoid arthritis; Juvenile rheumatoid arthritis from age 2 years; ankylosing spondylitis; Acute pain in adults · Common side effects — Diarrhea; Peripheral edema; Upper respiratory tract infection · Warnings — Sulfonamide allergy; aspirin/NSAID allergy; Hepatotoxicity; renal toxicity; Heart failure, hypertension, fetal toxicity · Interactions — Aspirin (analgesic doses)
Mechanism: Has analgesic, anti-inflammatory and antipyretic effects. The mechanism is incompletely understood but involves COX-1/COX-2 inhibition and reduced prostaglandin synthesis.
On both cards: Common side effects — Dyspepsia; Abdominal pain; Nausea; Headache
Only on the Diclofenac (oral) card: Used for — Osteoarthritis; Rheumatoid arthritis; Ankylosing spondylitis · Common side effects — Diarrhea · Warnings — Aspirin- or NSAID-induced allergy (contraindicated); CABG surgery setting (contraindicated) · Interactions — Anticoagulants (warfarin); Drugs interfering with hemostasis (SSRIs)
Mechanism: Mechanism is incompletely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin synthesis may contribute to its peripheral effects.
On both cards: Common side effects — Dyspepsia; Nausea; Headache
Only on the Indomethacin card: Used for — Moderate-to-severe rheumatoid arthritis, including acute flares; Moderate-to-severe ankylosing spondylitis; Moderate-to-severe osteoarthritis; Acute painful shoulder caused by bursitis and/or tendinitis · Common side effects — Dizziness · Warnings — Hepatotoxicity; Heart failure and edema; Renal toxicity · Interactions — Anticoagulants (e.g., warfarin); Aspirin and antiplatelets; SSRIs and SNRIs
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Ibuprofen: NSAIDs increase risk of serious CV thrombotic events and GI bleeding, ulceration and perforation; not for CABG setting.
Meloxicam: NSAIDs can cause serious, potentially fatal cardiovascular thrombotic events and GI bleeding, ulceration or perforation. Meloxicam is contraindicated in the coronary artery bypass graft surgery setting.
Diclofenac (oral): Increased risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration and perforation.
Diclofenac (topical): NSAIDs increase the risk of potentially fatal cardiovascular thrombotic events (including MI and stroke) and gastrointestinal bleeding, ulceration and perforation. This topical solution is contraindicated in the setting of CABG surgery.
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