Nabumetone: study card

Nabumetone — NSAID (prodrug). Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Nabumetone
Class
NSAID (prodrug)
Mechanism
Prodrug converted in the liver to 6MNA, a potent inhibitor of prostaglandin synthesis.
Used for
Relief of osteoarthritis signs and symptoms in adults; Relief of rheumatoid arthritis signs and symptoms in adults
Common side effects
Diarrhea; Dyspepsia; Abdominal pain; Constipation; Flatulence
Boxed warning
NSAIDs raise the risk of serious CV thrombotic events and GI bleeding, ulceration, and perforation, which can be fatal; not for CABG.
Warnings
Contraindicated in CABG setting; Aspirin/NSAID-induced asthma or urticaria
Interactions
ACE inhibitors; Diuretics (furosemide, thiazides); Lithium

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Drug class families: Nonsteroidal anti-inflammatory drugs

Read the source label ↗

Label date: 20260819 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Nabumetone: na-BUE-me-tone

Pronunciation is shown for the US English generic name.

Other drugs in the same class

Nonsteroidal anti-inflammatory drugs: Etodolac, Ibuprofen, Meloxicam, Aspirin, Naproxen, Celecoxib, Diclofenac (oral), Diclofenac (topical)

Body system

Musculoskeletal · 10 Drug cards

Compare with related cards

Celecoxib

Same class family: Nonsteroidal anti-inflammatory drugs

Mechanism: Has analgesic, anti-inflammatory and antipyretic effects; its mechanism is believed to involve reduced prostaglandin synthesis, primarily through COX-2 inhibition.

On both cards: Common side effects — Diarrhea; Dyspepsia; Abdominal pain

Only on the Celecoxib card: Used for — Signs and symptoms of osteoarthritis or rheumatoid arthritis; Juvenile rheumatoid arthritis from age 2 years; ankylosing spondylitis; Acute pain in adults; Primary dysmenorrhea · Common side effects — Peripheral edema; Upper respiratory tract infection · Warnings — Sulfonamide allergy; aspirin/NSAID allergy; Hepatotoxicity; renal toxicity; Heart failure, hypertension, fetal toxicity · Interactions — Anticoagulants / antiplatelets; SSRIs / SNRIs (bleeding); Aspirin (analgesic doses)

Diclofenac (oral)

Same class family: Nonsteroidal anti-inflammatory drugs

Mechanism: Has analgesic, anti-inflammatory and antipyretic effects. The mechanism is incompletely understood but involves COX-1/COX-2 inhibition and reduced prostaglandin synthesis.

On both cards: Common side effects — Diarrhea; Dyspepsia; Abdominal pain

Only on the Diclofenac (oral) card: Used for — Osteoarthritis; Rheumatoid arthritis; Ankylosing spondylitis · Common side effects — Nausea; Headache · Warnings — Aspirin- or NSAID-induced allergy (contraindicated); CABG surgery setting (contraindicated) · Interactions — Anticoagulants (warfarin); Drugs interfering with hemostasis (SSRIs)

Etodolac

Same class family: Nonsteroidal anti-inflammatory drugs

Mechanism: Shows anti-inflammatory, analgesic and antipyretic activity in animal models. Its mechanism is not completely understood and may involve prostaglandin-synthetase inhibition.

On both cards: Common side effects — Diarrhea; Dyspepsia; Abdominal pain

Only on the Etodolac card: Used for — Signs and symptoms of osteoarthritis or rheumatoid arthritis in adults; Acute pain in adults · Common side effects — Nausea; Dizziness · Warnings — Asthma or allergy after aspirin/other NSAIDs; New or worsening hypertension, heart failure; Hepatic reactions, elevated liver tests · Interactions — Warfarin (synergistic GI bleeding); ACE inhibitors, thiazide and loop diuretics; Lithium, methotrexate, cyclosporine, digoxin

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Same boxed-warning wording on: Indomethacin, Etodolac

Ibuprofen: NSAIDs increase risk of serious CV thrombotic events and GI bleeding, ulceration and perforation; not for CABG setting.

Meloxicam: NSAIDs can cause serious, potentially fatal cardiovascular thrombotic events and GI bleeding, ulceration or perforation. Meloxicam is contraindicated in the coronary artery bypass graft surgery setting.

Naproxen: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.

Celecoxib: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.