Indomethacin — NSAID. Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Indomethacin
Class
NSAID
Mechanism
Mechanism is incompletely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin synthesis may contribute to its peripheral effects.
Used for
Moderate-to-severe rheumatoid arthritis, including acute flares; Moderate-to-severe ankylosing spondylitis; Moderate-to-severe osteoarthritis; Acute painful shoulder caused by bursitis and/or tendinitis
Common side effects
Headache; Dizziness; Dyspepsia; Nausea
Boxed warning
NSAIDs raise the risk of serious CV thrombotic events and GI bleeding, ulceration, and perforation, which can be fatal; not for CABG.
Warnings
Hepatotoxicity; Heart failure and edema; Renal toxicity
Interactions
Anticoagulants (e.g., warfarin); Aspirin and antiplatelets; SSRIs and SNRIs
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260817 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Inhibits cyclooxygenase (COX-1 and COX-2) and prostaglandin synthesis; analgesic, anti-inflammatory and antipyretic.
On both cards: Common side effects — Dyspepsia · Warnings — Hepatotoxicity; Heart failure and edema; Renal toxicity
Only on the Meloxicam card: Used for — Relief of osteoarthritis signs and symptoms; Relief of rheumatoid arthritis signs and symptoms; Pauciarticular or polyarticular juvenile rheumatoid arthritis in patients weighing at least 60 kg · Common side effects — Diarrhea; Upper respiratory tract infection; Influenza-like symptoms · Interactions — Anticoagulants (e.g. warfarin); SSRIs / SNRIs
Mechanism: Has analgesic, antipyretic and anti-inflammatory effects. The selected label says the mechanism is not fully understood and may involve inhibition of prostaglandin synthesis.
On both cards: Common side effects — Dizziness; Nausea · Warnings — Renal toxicity
Only on the Ibuprofen card: Used for — Rheumatoid arthritis and osteoarthritis; Mild to moderate pain; Primary dysmenorrhea · Common side effects — Heartburn; Rash · Warnings — Around 20 weeks of pregnancy onward: fetal kidney injury and low amniotic fluid; restrict use between about 20 and 30 weeks; Avoid at about 30 weeks of pregnancy onward because the fetal ductus arteriosus can close prematurely; Hypertension and heart failure · Interactions — ACE inhibitors; Low-dose aspirin (reduced effect); Anticoagulants
Mechanism: Has analgesic, anti-inflammatory and antipyretic effects. The mechanism is not completely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin production may contribute.
On both cards: Common side effects — Headache; Dyspepsia; Nausea
Only on the Naproxen card: Used for — Rheumatoid arthritis, osteoarthritis, AS; Tendonitis, bursitis, acute gout; Pain; Primary dysmenorrhea · Common side effects — Abdominal pain; Edema · Warnings — Aspirin-sensitive asthma / NSAID allergy; Renal toxicity and hyperkalemia; Hepatotoxicity, heart failure, fetal toxicity · Interactions — Anticoagulants / antiplatelets; SSRIs / SNRIs (bleeding); Low-dose aspirin
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Ibuprofen: NSAIDs increase risk of serious CV thrombotic events and GI bleeding, ulceration and perforation; not for CABG setting.
Meloxicam: NSAIDs can cause serious, potentially fatal cardiovascular thrombotic events and GI bleeding, ulceration or perforation. Meloxicam is contraindicated in the coronary artery bypass graft surgery setting.
Naproxen: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.
Celecoxib: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.
Capsera