Diclofenac (oral) — NSAID (COX-1/COX-2 inhibitor). Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Diclofenac
Class
NSAID (COX-1/COX-2 inhibitor)
Mechanism
Has analgesic, anti-inflammatory and antipyretic effects. The mechanism is incompletely understood but involves COX-1/COX-2 inhibition and reduced prostaglandin synthesis.
Increased risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration and perforation.
Warnings
Aspirin- or NSAID-induced allergy (contraindicated); CABG surgery setting (contraindicated)
Interactions
Anticoagulants (warfarin); Drugs interfering with hemostasis (SSRIs)
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260629 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Has analgesic, anti-inflammatory and antipyretic effects. The mechanism is not completely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin production may contribute.
On both cards: Common side effects — Abdominal pain; Dyspepsia; Nausea; Headache
Only on the Naproxen card: Used for — Rheumatoid arthritis, osteoarthritis, AS; Tendonitis, bursitis, acute gout; Pain; Primary dysmenorrhea · Common side effects — Edema · Warnings — Aspirin-sensitive asthma / NSAID allergy; Renal toxicity and hyperkalemia; Hepatotoxicity, heart failure, fetal toxicity · Interactions — Anticoagulants / antiplatelets; SSRIs / SNRIs (bleeding); Low-dose aspirin
Mechanism: Shows anti-inflammatory, analgesic and antipyretic activity in animal models. Its mechanism is not completely understood and may involve prostaglandin-synthetase inhibition.
On both cards: Common side effects — Abdominal pain; Dyspepsia; Nausea; Diarrhea
Only on the Etodolac card: Used for — Signs and symptoms of osteoarthritis or rheumatoid arthritis in adults; Acute pain in adults · Common side effects — Dizziness · Warnings — Asthma or allergy after aspirin/other NSAIDs; New or worsening hypertension, heart failure; Hepatic reactions, elevated liver tests · Interactions — Warfarin (synergistic GI bleeding); ACE inhibitors, thiazide and loop diuretics; Lithium, methotrexate, cyclosporine, digoxin
Mechanism: Has analgesic, anti-inflammatory and antipyretic effects; its mechanism is believed to involve reduced prostaglandin synthesis, primarily through COX-2 inhibition.
On both cards: Common side effects — Abdominal pain; Dyspepsia; Diarrhea
Only on the Celecoxib card: Used for — Signs and symptoms of osteoarthritis or rheumatoid arthritis; Juvenile rheumatoid arthritis from age 2 years; ankylosing spondylitis; Acute pain in adults; Primary dysmenorrhea · Common side effects — Peripheral edema; Upper respiratory tract infection · Warnings — Sulfonamide allergy; aspirin/NSAID allergy; Hepatotoxicity; renal toxicity; Heart failure, hypertension, fetal toxicity · Interactions — Anticoagulants / antiplatelets; SSRIs / SNRIs (bleeding); Aspirin (analgesic doses)
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Boxed warnings on related cards
Ibuprofen: NSAIDs increase risk of serious CV thrombotic events and GI bleeding, ulceration and perforation; not for CABG setting.
Meloxicam: NSAIDs can cause serious, potentially fatal cardiovascular thrombotic events and GI bleeding, ulceration or perforation. Meloxicam is contraindicated in the coronary artery bypass graft surgery setting.
Naproxen: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.
Celecoxib: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.
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