Ibuprofen — Nonsteroidal anti-inflammatory drug (NSAID). Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Ibuprofen
Class
Nonsteroidal anti-inflammatory drug (NSAID)
Mechanism
Has analgesic, antipyretic and anti-inflammatory effects. The selected label says the mechanism is not fully understood and may involve inhibition of prostaglandin synthesis.
Used for
Rheumatoid arthritis and osteoarthritis; Mild to moderate pain; Primary dysmenorrhea
Common side effects
Nausea; Heartburn; Dizziness; Rash
Boxed warning
NSAIDs increase risk of serious CV thrombotic events and GI bleeding, ulceration and perforation; not for CABG setting.
Warnings
Around 20 weeks of pregnancy onward: fetal kidney injury and low amniotic fluid; restrict use between about 20 and 30 weeks; Avoid at about 30 weeks of pregnancy onward because the fetal ductus arteriosus can close prematurely; Hypertension and heart failure; Renal toxicity
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260220 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Mechanism is incompletely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin synthesis may contribute to its peripheral effects.
On both cards: Common side effects — Nausea; Dizziness · Warnings — Renal toxicity
Only on the Indomethacin card: Used for — Moderate-to-severe rheumatoid arthritis, including acute flares; Moderate-to-severe ankylosing spondylitis; Moderate-to-severe osteoarthritis; Acute painful shoulder caused by bursitis and/or tendinitis · Common side effects — Headache; Dyspepsia · Warnings — Hepatotoxicity; Heart failure and edema · Interactions — Anticoagulants (e.g., warfarin); Aspirin and antiplatelets; SSRIs and SNRIs
Mechanism: Has analgesic, anti-inflammatory and antipyretic effects. The mechanism is not completely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin production may contribute.
On both cards: Used for — Primary dysmenorrhea · Common side effects — Nausea
Only on the Naproxen card: Used for — Rheumatoid arthritis, osteoarthritis, AS; Tendonitis, bursitis, acute gout; Pain · Common side effects — Dyspepsia; Abdominal pain; Headache; Edema · Warnings — Aspirin-sensitive asthma / NSAID allergy; Renal toxicity and hyperkalemia; Hepatotoxicity, heart failure, fetal toxicity · Interactions — Anticoagulants / antiplatelets; SSRIs / SNRIs (bleeding); Low-dose aspirin
Mechanism: Shows anti-inflammatory, analgesic and antipyretic activity in animal models. Its mechanism is not completely understood and may involve prostaglandin-synthetase inhibition.
On both cards: Common side effects — Nausea; Dizziness
Only on the Etodolac card: Used for — Signs and symptoms of osteoarthritis or rheumatoid arthritis in adults; Acute pain in adults · Common side effects — Dyspepsia; Abdominal pain; Diarrhea · Warnings — Asthma or allergy after aspirin/other NSAIDs; New or worsening hypertension, heart failure; Hepatic reactions, elevated liver tests · Interactions — Warfarin (synergistic GI bleeding); ACE inhibitors, thiazide and loop diuretics; Lithium, methotrexate, cyclosporine, digoxin
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Boxed warnings on related cards
Meloxicam: NSAIDs can cause serious, potentially fatal cardiovascular thrombotic events and GI bleeding, ulceration or perforation. Meloxicam is contraindicated in the coronary artery bypass graft surgery setting.
Naproxen: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.
Celecoxib: NSAIDs raise risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration, perforation; contraindicated in CABG.
Diclofenac (oral): Increased risk of serious CV thrombotic events (MI, stroke) and GI bleeding, ulceration and perforation.
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