CapseraAngiotensin II receptor blockers
Compare the named medicines in this source-linked class directory.
Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.
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Combination: membership refers to the relevant component.
Combination: membership refers to the relevant component.
Combination: membership refers to the relevant component.
Generic names and pronunciation
Shared name ending: -sartan · Losartan, Valsartan, Irbesartan, Telmisartan
| Losartan · loe-SAR-tan |
| Hydrochlorothiazide · hye-droe-klor-oh-THYE-a-zide |
| Valsartan · val-SAR-tan |
| Olmesartan · ol-me-SAR-tan |
| Amlodipine · am-LOE-di-peen |
| Irbesartan · ir-be-SAR-tan |
| Telmisartan · tel-mi-SAR-tan |
| Sacubitril · sak-UE-bi-tril |
Pronunciation is shown for the US English generic name. A name ending is a memory cue, not a classification rule.
Body system and related classes
Body system: Cardiovascular
How each medicine works
| Losartan — Losartan and its active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II at its receptor. |
| Losartan / Hydrochlorothiazide — Losartan selectively blocks angiotensin II binding at AT1 receptors; hydrochlorothiazide increases renal sodium and chloride excretion. |
| Valsartan — Selectively blocks angiotensin II binding to AT1 receptors, inhibiting its vasoconstrictor and aldosterone-secreting effects. |
| Olmesartan / Amlodipine / Hydrochlorothiazide — Olmesartan blocks angiotensin II effects, amlodipine blocks calcium entry into vascular smooth muscle, and HCTZ promotes sodium and chloride excretion. |
| Irbesartan — Blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II at its receptor. |
| Telmisartan — Blocks angiotensin II at the AT1 receptor, reducing vasoconstriction and aldosterone release. |
| Sacubitril / Valsartan — Sacubitril (via LBQ657) inhibits neprilysin; valsartan blocks the AT1 receptor. |
Each summary is the mechanism line from the medicine’s study card.
What each medicine is used for
| Losartan — Hypertension in adults and children aged 6 years and older; Stroke-risk reduction in hypertension with left ventricular hypertrophy; the label reports that this benefit did not apply to Black patients; Diabetic nephropathy with elevated serum creatinine and proteinuria in type 2 diabetes with a history of hypertension |
| Losartan / Hydrochlorothiazide — Hypertension; this fixed-dose combination is not initial therapy except in selected severe cases where prompt control outweighs combination-initiation risk; Stroke-risk reduction in hypertension with left ventricular hypertrophy; the label reports evidence that this specific benefit does not apply to Black patients |
| Valsartan — Hypertension in adults and children aged 6 years and older; Reduction of heart-failure hospitalization in adults with NYHA class II–IV heart failure; Reduction of cardiovascular mortality in clinically stable adults with left ventricular failure or dysfunction after myocardial infarction |
| Olmesartan / Amlodipine / Hydrochlorothiazide — Hypertension requiring the selected olmesartan/amlodipine/hydrochlorothiazide combination; not indicated for initial therapy |
| Irbesartan — Hypertension; Diabetic nephropathy in patients with type 2 diabetes, hypertension, elevated serum creatinine and proteinuria greater than 300 mg/day |
| Telmisartan — Hypertension in adults; Reduction of myocardial infarction, stroke or cardiovascular death risk in adults aged 55 years and older at high cardiovascular risk who cannot take ACE inhibitors |
| Sacubitril / Valsartan — Reduction of cardiovascular death and heart-failure hospitalization in adults with chronic heart failure; benefit is most evident when LVEF is below normal; Symptomatic heart failure with systemic left ventricular systolic dysfunction in children aged 1 year and older |
Each list is the uses line from the medicine’s study card.
Telling these medicines apart
Medicines in this class: 7 · single-ingredient: 4 · combination products: 3
Not in the reviewed -sartan name-ending list: Losartan / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide, Sacubitril / Valsartan
Also in other drug classes: Losartan / Hydrochlorothiazide (Thiazide and thiazide-like diuretics) · Olmesartan / Amlodipine / Hydrochlorothiazide (Dihydropyridine calcium channel blockers, Thiazide and thiazide-like diuretics)
Listed on more than one card in this class
Used for
Hypertension in adults and children aged 6 years and older · 2/7: Losartan, Valsartan
Common side effects
Dizziness · 6/7: Losartan, Losartan / Hydrochlorothiazide, Valsartan, Olmesartan / Amlodipine / Hydrochlorothiazide, Irbesartan, Sacubitril / Valsartan
Back pain · 3/7: Losartan, Losartan / Hydrochlorothiazide, Telmisartan
Hyperkalemia · 3/7: Valsartan, Irbesartan, Sacubitril / Valsartan
Upper respiratory infection · 2/7: Losartan, Losartan / Hydrochlorothiazide
Cough · 2/7: Losartan / Hydrochlorothiazide, Sacubitril / Valsartan
Headache · 2/7: Valsartan, Olmesartan / Amlodipine / Hydrochlorothiazide
Fatigue · 2/7: Valsartan, Olmesartan / Amlodipine / Hydrochlorothiazide
Hypotension · 2/7: Valsartan, Sacubitril / Valsartan
Warnings
Hypotension in volume-depleted patients · 3/7: Losartan, Losartan / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide
Hypotension · 3/7: Valsartan, Telmisartan, Sacubitril / Valsartan
Interactions
Lithium · 6/7: Losartan, Losartan / Hydrochlorothiazide, Valsartan, Olmesartan / Amlodipine / Hydrochlorothiazide, Irbesartan, Sacubitril / Valsartan
NSAIDs · 4/7: Losartan, Losartan / Hydrochlorothiazide, Valsartan, Olmesartan / Amlodipine / Hydrochlorothiazide
Potassium-raising agents · 2/7: Losartan, Losartan / Hydrochlorothiazide
Boxed warning
7/7: Losartan, Losartan / Hydrochlorothiazide, Valsartan, Olmesartan / Amlodipine / Hydrochlorothiazide, Irbesartan, Telmisartan, Sacubitril / Valsartan
Same boxed-warning wording on: Losartan / Hydrochlorothiazide, Valsartan
Same boxed-warning wording on: Olmesartan / Amlodipine / Hydrochlorothiazide, Irbesartan
Same boxed-warning wording on: Telmisartan, Sacubitril / Valsartan
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.