CapseraThiazide and thiazide-like diuretics
Compare the named medicines in this source-linked class directory.
Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.
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Combination: membership refers to the relevant component.
Combination: membership refers to the relevant component.
Combination: membership refers to the relevant component.
Combination: membership refers to the relevant component.
This medicine has additional actions; this family describes only one of them.
Generic names and pronunciation
| Hydrochlorothiazide · hye-droe-klor-oh-THYE-a-zide |
| Lisinopril · ly-SIN-oh-pril |
| Losartan · loe-SAR-tan |
| Olmesartan · ol-me-SAR-tan |
| Amlodipine · am-LOE-di-peen |
| Triamterene · trye-AM-ter-een |
| Chlorthalidone · klor-THAL-i-done |
Pronunciation is shown for the US English generic name.
Body system and related classes
Body system: Cardiovascular
How each medicine works
| Hydrochlorothiazide — Affects distal renal tubular electrolyte reabsorption and increases sodium and chloride excretion. The selected label describes the mechanism of its antihypertensive effect as unknown. |
| Lisinopril / Hydrochlorothiazide — Lisinopril inhibits ACE, lowering angiotensin II and aldosterone; hydrochlorothiazide is a thiazide diuretic. |
| Losartan / Hydrochlorothiazide — Losartan selectively blocks angiotensin II binding at AT1 receptors; hydrochlorothiazide increases renal sodium and chloride excretion. |
| Olmesartan / Amlodipine / Hydrochlorothiazide — Olmesartan blocks angiotensin II effects, amlodipine blocks calcium entry into vascular smooth muscle, and HCTZ promotes sodium and chloride excretion. |
| Triamterene / Hydrochlorothiazide — HCTZ blocks renal tubular sodium and chloride reabsorption; triamterene inhibits distal sodium reabsorption, reducing potassium loss. |
| Chlorthalidone — A long-acting oral diuretic that increases sodium and chloride excretion. Its site of action appears to be the cortical diluting segment of the ascending limb of Henle’s loop; the antihypertensive mechanism is not wholly clear. |
Each summary is the mechanism line from the medicine’s study card.
What each medicine is used for
| Hydrochlorothiazide — Hypertension, alone or with other antihypertensive medicines; Adjunctive treatment of edema associated with congestive heart failure or hepatic cirrhosis; Edema associated with specified forms of renal dysfunction |
| Lisinopril / Hydrochlorothiazide — Hypertension when this fixed-dose combination is appropriate; it is not indicated for initial therapy |
| Losartan / Hydrochlorothiazide — Hypertension; this fixed-dose combination is not initial therapy except in selected severe cases where prompt control outweighs combination-initiation risk; Stroke-risk reduction in hypertension with left ventricular hypertrophy; the label reports evidence that this specific benefit does not apply to Black patients |
| Olmesartan / Amlodipine / Hydrochlorothiazide — Hypertension requiring the selected olmesartan/amlodipine/hydrochlorothiazide combination; not indicated for initial therapy |
| Triamterene / Hydrochlorothiazide — Hypertension or edema with hypokalemia on HCTZ; Thiazide need where hypokalemia can't be risked |
| Chlorthalidone — Hypertension in adults |
Each list is the uses line from the medicine’s study card.
Telling these medicines apart
Medicines in this class: 6 · single-ingredient: 2 · combination products: 4
Also in other drug classes: Lisinopril / Hydrochlorothiazide (ACE inhibitors) · Losartan / Hydrochlorothiazide (Angiotensin II receptor blockers) · Olmesartan / Amlodipine / Hydrochlorothiazide (Angiotensin II receptor blockers, Dihydropyridine calcium channel blockers)
Chlorthalidone — Thiazide-like rather than a thiazide by chemical structure; the label describes a monosulfamyl diuretic with a different ring structure.
Listed on more than one card in this class
Common side effects
Dizziness · 5/6: Lisinopril / Hydrochlorothiazide, Losartan / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide, Triamterene / Hydrochlorothiazide, Chlorthalidone
Headache · 4/6: Lisinopril / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide, Triamterene / Hydrochlorothiazide, Chlorthalidone
Nausea · 3/6: Hydrochlorothiazide, Triamterene / Hydrochlorothiazide, Chlorthalidone
Fatigue · 3/6: Lisinopril / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide, Triamterene / Hydrochlorothiazide
Photosensitivity · 2/6: Hydrochlorothiazide, Chlorthalidone
Cough · 2/6: Lisinopril / Hydrochlorothiazide, Losartan / Hydrochlorothiazide
Warnings
Hypotension in volume-depleted patients · 2/6: Losartan / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide
Interactions
Lithium · 4/6: Losartan / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide, Triamterene / Hydrochlorothiazide, Chlorthalidone
NSAIDs · 2/6: Losartan / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide
Boxed warning
4/6: Lisinopril / Hydrochlorothiazide, Losartan / Hydrochlorothiazide, Olmesartan / Amlodipine / Hydrochlorothiazide, Triamterene / Hydrochlorothiazide
Same boxed-warning wording on: Lisinopril / Hydrochlorothiazide, Losartan / Hydrochlorothiazide
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.