CapseraLoop diuretics
Compare the named medicines in this source-linked class directory.
Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.
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Generic names and pronunciation
| Furosemide · fyoo-ROE-se-mide |
| Torsemide · TORE-se-mide |
| Bumetanide · byoo-MET-a-nide |
Pronunciation is shown for the US English generic name.
Body system and related classes
Body system: Cardiovascular
How each medicine works
| Furosemide — Inhibits sodium and chloride reabsorption in the loop of Henle and the proximal and distal tubules. |
| Torsemide — Animal micropuncture studies show inhibition of the Na+/K+/2Cl− carrier from the lumen of the thick ascending loop of Henle, producing diuresis. |
| Bumetanide — Loop diuretic; inhibits sodium and chloride reabsorption in the ascending limb of the loop of Henle. |
Each summary is the mechanism line from the medicine’s study card.
What each medicine is used for
| Furosemide — Edema associated with congestive heart failure, hepatic cirrhosis or renal disease in adults and children; Hypertension in adults, alone or with other antihypertensive medicines |
| Torsemide — Edema (heart failure, renal or hepatic disease); Hypertension |
| Bumetanide — Edema associated with congestive heart failure in adults; Edema associated with hepatic disease in adults; Edema associated with renal disease, including nephrotic syndrome, in adults |
Each list is the uses line from the medicine’s study card.
Telling these medicines apart
Medicines in this class: 3
Listed on more than one card in this class
Common side effects
Nausea · 2/3: Furosemide, Bumetanide
Dizziness · 2/3: Furosemide, Bumetanide
Hypotension · 2/3: Torsemide, Bumetanide
Warnings
Ototoxicity · 2/3: Furosemide, Torsemide
Interactions
Lithium · 2/3: Furosemide, Torsemide
Boxed warning
1/3: Bumetanide
Listed on only one card in this class
Furosemide: Common side effects — Anorexia; Photosensitivity · Warnings — Fluid and electrolyte depletion; Hepatic coma in cirrhosis · Interactions — Aminoglycosides (ototoxicity); High-dose salicylates
Torsemide: Common side effects — Excessive urination; Electrolyte abnormalities · Warnings — Hypotension / worsening renal function; Electrolyte and metabolic abnormalities · Interactions — NSAIDs; CYP2C9 substrates (warfarin, phenytoin)
Bumetanide: Common side effects — Muscle cramps; Headache · Warnings — Contraindicated in anuria; Hepatic coma, severe electrolyte depletion; Serious skin reactions (SJS/TEN)
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.