Losartan / Hydrochlorothiazide — Angiotensin II receptor blocker + thiazide diuretic. Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Losartan / Hydrochlorothiazide
Class
Angiotensin II receptor blocker + thiazide diuretic
Mechanism
Losartan selectively blocks angiotensin II binding at AT1 receptors; hydrochlorothiazide increases renal sodium and chloride excretion.
Used for
Hypertension; this fixed-dose combination is not initial therapy except in selected severe cases where prompt control outweighs combination-initiation risk; Stroke-risk reduction in hypertension with left ventricular hypertrophy; the label reports evidence that this specific benefit does not apply to Black patients
Common side effects
Dizziness; Upper respiratory infection; Cough; Back pain
Boxed warning
Fetal toxicity: drugs acting on the renin-angiotensin system can injure or kill the developing fetus; stop when pregnancy is detected.
Warnings
Hypotension in volume-depleted patients; Renal function and electrolyte changes; Acute angle-closure glaucoma
Interactions
Potassium-raising agents; Lithium; NSAIDs
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260728 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Losartan and its active metabolite block the vasoconstrictor and aldosterone-secreting effects of angiotensin II at its receptor.
On both cards: Common side effects — Dizziness; Upper respiratory infection; Back pain · Warnings — Hypotension in volume-depleted patients · Interactions — Potassium-raising agents; Lithium; NSAIDs
Only on the Losartan card: Used for — Hypertension in adults and children aged 6 years and older; Stroke-risk reduction in hypertension with left ventricular hypertrophy; the label reports that this benefit did not apply to Black patients; Diabetic nephropathy with elevated serum creatinine and proteinuria in type 2 diabetes with a history of hypertension · Common side effects — Nasal congestion · Warnings — Renal function changes; Hyperkalemia
Mechanism: Olmesartan blocks angiotensin II effects, amlodipine blocks calcium entry into vascular smooth muscle, and HCTZ promotes sodium and chloride excretion.
On both cards: Common side effects — Dizziness · Warnings — Hypotension in volume-depleted patients · Interactions — Lithium; NSAIDs
Only on the Olmesartan / Amlodipine / Hydrochlorothiazide card: Used for — Hypertension requiring the selected olmesartan/amlodipine/hydrochlorothiazide combination; not indicated for initial therapy · Common side effects — Peripheral edema; Headache; Fatigue; Muscle spasms · Warnings — Fluid and electrolyte imbalance; Sprue-like enteropathy · Interactions — Aliskiren (in diabetes)
Mechanism: Selectively blocks angiotensin II binding to AT1 receptors, inhibiting its vasoconstrictor and aldosterone-secreting effects.
On both cards: Common side effects — Dizziness · Interactions — Lithium; NSAIDs
Only on the Valsartan card: Used for — Hypertension in adults and children aged 6 years and older; Reduction of heart-failure hospitalization in adults with NYHA class II–IV heart failure; Reduction of cardiovascular mortality in clinically stable adults with left ventricular failure or dysfunction after myocardial infarction · Common side effects — Headache; Fatigue; Hypotension; Hyperkalemia · Warnings — Hypotension; Renal function and potassium changes; No aliskiren in diabetes · Interactions — Potassium-sparing diuretics / supplements
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Triamterene / Hydrochlorothiazide: Hyperkalemia can occur with potassium-conserving diuretics; risk is higher in renal impairment, diabetes and the elderly.
Irbesartan: Fetal toxicity: drugs acting on the renin-angiotensin system can injure or kill the fetus; stop when pregnancy is detected.
Capsera