Progesterone — Progestogen (progesterone chemically identical to human ovarian progesterone). Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Progesterone
Class
Progestogen (progesterone chemically identical to human ovarian progesterone)
Mechanism
Transforms estrogen-primed proliferative endometrium into secretory endometrium.
Used for
Prevention of endometrial hyperplasia in postmenopausal women with a uterus who receive conjugated estrogen tablets; Secondary amenorrhea
Common side effects
Headache; Breast tenderness; Dizziness; Abdominal pain
Boxed warning
Estrogen plus progestin therapy carries cardiovascular, breast-cancer and probable-dementia risks and is not used to prevent cardiovascular disease or dementia. The cited dementia trial involved postmenopausal women aged 65 or older; applicability to younger women is unknown.
Warnings
DVT, PE, stroke risk; Breast cancer; These oral capsules contain peanut oil and are contraindicated in people with peanut allergy; The selected capsule label also contraindicates use with unexplained genital bleeding, liver disease or known or suspected pregnancy
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20240302 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-23. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Suppresses ovulation in about half of users, thickens cervical mucus, blunts LH/FSH peaks and alters the endometrium.
On both cards: Common side effects — Headache; Breast tenderness; Dizziness
Only on the Norethindrone card: Used for — Prevention of pregnancy · Common side effects — Menstrual irregularity; Nausea · Warnings — Known or suspected pregnancy (contraindicated); Breast carcinoma (contraindicated); Liver tumors or acute liver disease
Mechanism: Binds nuclear estrogen receptors; reduces the elevated LH and FSH seen after menopause via negative feedback.
On both cards: Common side effects — Headache; Breast tenderness
Only on the Estradiol (transdermal) card: Used for — Moderate-to-severe menopausal vasomotor symptoms; Postmenopausal osteoporosis prevention only after considering non-estrogen options and significant osteoporosis risk · Common side effects — Back pain; Nausea; Intermenstrual bleeding · Warnings — The label reports stroke/DVT risks with estrogen alone and stroke/DVT/PE/MI risks with studied estrogen-plus-progestin therapy; Gallbladder disease; Undiagnosed abnormal genital bleeding is a contraindication
Mechanism: Primarily suppresses ovulation; possible additional mechanisms include cervical-mucus changes that inhibit sperm penetration and endometrial changes that reduce implantation likelihood.
On both cards: Common side effects — Breast tenderness; Abdominal pain
Only on the Norgestimate / Ethinyl Estradiol card: Used for — Prevention of pregnancy · Common side effects — Headache / migraine; Nausea; Irregular uterine bleeding · Warnings — Thromboembolic disorders; Liver disease / jaundice; Hypertension
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Capsera