Rizatriptan: study card

Rizatriptan — Serotonin 5-HT1B/1D agonist (triptan). Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name: Rizatriptan
Class: Serotonin 5-HT1B/1D agonist (triptan)
Mechanism: Presumed to treat migraine by binding 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system.
Used for: Acute migraine with or without aura in adults and children aged 6–17 after a clear migraine diagnosis; not migraine prevention
Common side effects: Asthenia / fatigue; Somnolence; Pain / pressure sensation; Dizziness
Warnings: Myocardial ischemia / infarction, Prinzmetal's angina; Stroke and cerebral hemorrhage; Serotonin syndrome
Interactions: Propranolol; Ergot-containing drugs; Other 5-HT1 agonists

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Drug class families: 5-HT1B/1D receptor agonists

Read the source label ↗

Label date: 20260908 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Practice

Pronunciation

Rizatriptan: rye-za-TRIP-tan

Shared name ending: -triptan · Sumatriptan

Pronunciation is shown for the US English generic name. A name ending is a memory cue, not a classification rule.

Other drugs in the same class

5-HT1B/1D receptor agonists: Sumatriptan

Body system

Neurology · 18 Drug cards

Compare with related cards

Sumatriptan

Same class family: 5-HT1B/1D receptor agonists

Mechanism: Presumed to act in migraine through 5-HT1B/1D agonism on intracranial vessels and trigeminal sensory nerves, producing cranial vasoconstriction and reduced pro-inflammatory neuropeptide release.

Only on the Sumatriptan card: Used for — Acute treatment of migraine with or without aura in adults · Common side effects — Paresthesia; Warm/cold sensation; Chest pain / tightness; Neck/throat/jaw pressure; Vertigo · Warnings — Contraindicated in ischemic or vasospastic CAD; Stroke / TIA, WPW, uncontrolled hypertension; Serotonin syndrome; medication overuse headache · Interactions — Ergot-containing drugs / other 5-HT1 agonists; MAO-A inhibitors; SSRIs / SNRIs (serotonin syndrome)

Gabapentin

Same body system: Neurology

Mechanism: The exact analgesic and antiepileptic mechanisms are unknown. Gabapentin is structurally related to GABA but does not affect its binding, uptake or degradation. It binds the alpha-2-delta calcium-channel subunit in vitro; the relevance to therapeutic effects is unknown.

On both cards: Common side effects — Somnolence; Dizziness

Only on the Gabapentin card: Used for — Postherpetic neuralgia in adults; Adjunctive treatment of partial-onset seizures in adults and children aged 3 or older · Common side effects — Peripheral edema; Ataxia; Fatigue · Warnings — DRESS (multiorgan hypersensitivity); Respiratory depression with CNS depressants; Suicidal behavior and ideation · Interactions — Opioids; Antacids (aluminum/magnesium hydroxide)

Pregabalin

Same body system: Neurology

Mechanism: Binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in CNS tissue; exact mechanism not fully known.

On both cards: Common side effects — Somnolence; Dizziness

Only on the Pregabalin card: Used for — Diabetic peripheral-neuropathy pain in adults; Postherpetic neuralgia in adults; Adjunctive treatment of partial-onset seizures from age 1 month; Fibromyalgia in adults; Spinal-cord-injury neuropathic pain in adults · Common side effects — Dry mouth; Edema; Blurred vision · Warnings — Angioedema; Suicidal thoughts or behavior; Respiratory depression with CNS depressants

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.