Pregabalin — Alpha-2-delta calcium channel ligand (gabapentinoid). Study the mechanism, listed uses and warnings from the US label on one sourced card.
Binds with high affinity to the alpha-2-delta subunit of voltage-gated calcium channels in CNS tissue; exact mechanism not fully known.
Used for
Diabetic peripheral-neuropathy pain in adults; Postherpetic neuralgia in adults; Adjunctive treatment of partial-onset seizures from age 1 month; Fibromyalgia in adults; Spinal-cord-injury neuropathic pain in adults
Angioedema; Suicidal thoughts or behavior; Respiratory depression with CNS depressants
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260814 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: The exact analgesic and antiepileptic mechanisms are unknown. Gabapentin is structurally related to GABA but does not affect its binding, uptake or degradation. It binds the alpha-2-delta calcium-channel subunit in vitro; the relevance to therapeutic effects is unknown.
On both cards: Used for — Postherpetic neuralgia in adults · Common side effects — Dizziness; Somnolence · Warnings — Respiratory depression with CNS depressants
Only on the Gabapentin card: Used for — Adjunctive treatment of partial-onset seizures in adults and children aged 3 or older · Common side effects — Peripheral edema; Ataxia; Fatigue · Warnings — DRESS (multiorgan hypersensitivity); Suicidal behavior and ideation
Mechanism: The precise antiepileptic mechanism is unknown. Experimental data identify a binding site as synaptic vesicle protein SV2A, thought to regulate vesicle exocytosis; interaction with SV2A may contribute to the antiepileptic effect.
On both cards: Common side effects — Dizziness; Somnolence
Only on the Levetiracetam card: Used for — Partial-onset seizures from age 1 month; Adjunctive treatment of myoclonic seizures in juvenile myoclonic epilepsy from age 12; Adjunctive treatment of primary generalized tonic-clonic seizures in idiopathic generalized epilepsy from age 6 · Common side effects — Asthenia; Infection; Irritability (children) · Warnings — Behavioral abnormalities / psychotic symptoms; Suicidal behavior and ideation; Withdrawal seizures if stopped abruptly
Mechanism: Presumed to treat migraine by binding 5-HT1B/1D receptors on intracranial blood vessels and sensory nerves of the trigeminal system.
On both cards: Common side effects — Dizziness; Somnolence
Only on the Rizatriptan card: Used for — Acute migraine with or without aura in adults and children aged 6–17 after a clear migraine diagnosis; not migraine prevention · Common side effects — Asthenia / fatigue; Pain / pressure sensation · Warnings — Myocardial ischemia / infarction, Prinzmetal's angina; Stroke and cerebral hemorrhage; Serotonin syndrome
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Capsera