Metronidazole (oral): study card

Metronidazole (oral) — Nitroimidazole antimicrobial. Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Metronidazole
Class
Nitroimidazole antimicrobial
Mechanism
In susceptible anaerobic bacteria, metronidazole is reduced to reactive intermediates that can inhibit DNA synthesis and degrade DNA, leading to bacterial death. Its precise mechanism of action is unclear.
Used for
Confirmed or otherwise specifically indicated Trichomonas vaginalis infection and selected partner-treatment settings; Acute intestinal amebiasis or amebic liver abscess; Serious infections caused by susceptible anaerobic bacteria
Common side effects
Nausea; Metallic taste; Headache; Peripheral neuropathy
Boxed warning
Carcinogenic in mice and rats; avoid unnecessary use.
Warnings
Encephalopathy and peripheral neuropathy; Contraindicated with recent disulfiram use
Interactions
Alcohol (disulfiram-like reaction); Disulfiram; Warfarin

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260826 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Metronidazole: me-troe-NI-da-zole

Pronunciation is shown for the US English generic name.

Body system

Infectious disease · 21 Drug cards

Compare with related cards

Levofloxacin

Same body system: Infectious disease

Mechanism: Fluoroquinolone antibacterial active against designated susceptible bacteria.

On both cards: Common side effects — Nausea; Headache · Interactions — Warfarin

Only on the Levofloxacin card: Used for — Adult nosocomial or community-acquired pneumonia caused by the specified susceptible organisms; Adult complicated UTI; uncomplicated UTI only when no alternative treatment options exist; Adult acute bacterial sinusitis only when no alternative treatment options exist; Post-exposure inhalational anthrax and treatment/prophylaxis of plague in adults and children aged 6 months or older; pediatric formulation/weight restrictions apply · Common side effects — Diarrhea; Insomnia; Dizziness · Warnings — QT prolongation; Hepatotoxicity; C. difficile-associated diarrhea · Interactions — Antacids / multivalent cations; Antidiabetic agents

Azithromycin

Same body system: Infectious disease

Mechanism: Binds to the bacterial 50S ribosomal subunit and interrupts protein synthesis.

On both cards: Common side effects — Nausea · Interactions — Warfarin

Only on the Azithromycin card: Used for — Community-acquired pneumonia caused by the specified susceptible bacteria in adults or children aged 6 months and older who are appropriate for oral treatment; Streptococcal pharyngitis or tonsillitis in adults or children aged 2 years and older who cannot use first-line therapy; Acute otitis media caused by the specified susceptible bacteria in children aged 6 months and older; Urethritis or cervicitis caused by the specified susceptible organisms in adults · Common side effects — Diarrhea; Abdominal pain; Vomiting · Warnings — Serious allergic and skin reactions; Hepatotoxicity; QT prolongation / torsades de pointes · Interactions — Nelfinavir

Valacyclovir

Same body system: Infectious disease

Mechanism: Deoxynucleoside analogue DNA polymerase inhibitor; antiviral active against alpha-herpes viruses.

On both cards: Common side effects — Nausea; Headache

Only on the Valacyclovir card: Used for — Cold sores in adults and children aged 12 or older; Genital-herpes treatment and suppression in the adult populations specified by the label; Herpes zoster in immunocompetent adults; Chickenpox in immunocompetent children aged 2 to under 18 · Common side effects — Abdominal pain · Warnings — TTP / HUS; Acute renal failure; CNS reactions (agitation, confusion)

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Other cards with a boxed warning in this body system (Infectious disease): Nirmatrelvir / Ritonavir, Ciprofloxacin, Clindamycin phosphate, Levofloxacin, Emtricitabine / Tenofovir Disoproxil Fumarate