Nirmatrelvir / Ritonavir: brand names and study card
Nirmatrelvir / Ritonavir — SARS-CoV-2 Mpro inhibitor + CYP3A inhibitor booster. Study the mechanism, listed uses and warnings from the US label on one sourced card.
Nirmatrelvir inhibits SARS-CoV-2 main protease (3CLpro); ritonavir inhibits CYP3A metabolism of nirmatrelvir, raising its levels.
Used for
Mild-to-moderate COVID-19, high-risk adults
Common side effects
Dysgeusia; Diarrhea
Boxed warning
Significant drug interactions: ritonavir, a strong CYP3A inhibitor, may raise levels of other drugs to life-threatening or fatal levels.
Warnings
Hypersensitivity incl. TEN / SJS; Hepatotoxicity; HIV-1 protease inhibitor resistance
Interactions
CYP3A-dependent drugs whose elevated concentrations can cause serious or life-threatening reactions are contraindicated; Strong CYP3A inducers; CYP2D6, P-gp and OATP1B1 substrates; interaction management depends on the specific medicine
Label date: 20260219 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Binds to the bacterial 50S ribosomal subunit and interrupts protein synthesis.
On both cards: Common side effects — Diarrhea · Warnings — Hepatotoxicity
Only on the Azithromycin card: Used for — Community-acquired pneumonia caused by the specified susceptible bacteria in adults or children aged 6 months and older who are appropriate for oral treatment; Streptococcal pharyngitis or tonsillitis in adults or children aged 2 years and older who cannot use first-line therapy; Acute otitis media caused by the specified susceptible bacteria in children aged 6 months and older; Urethritis or cervicitis caused by the specified susceptible organisms in adults · Common side effects — Nausea; Abdominal pain; Vomiting · Warnings — Serious allergic and skin reactions; QT prolongation / torsades de pointes · Interactions — Nelfinavir; Warfarin
Mechanism: Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, disrupting processes required for bacterial DNA replication and maintenance.
On both cards: Common side effects — Diarrhea · Warnings — Hepatotoxicity
Only on the Ciprofloxacin card: Used for — UTIs due to specified susceptible bacteria in adults, and selected complicated UTI/pyelonephritis in children aged 1–17; acute uncomplicated cystitis use is reserved for patients without alternatives; Specified susceptible lower-respiratory infections in adults; acute chronic-bronchitis exacerbation use is reserved for patients without alternatives; Specified susceptible skin, bone and joint infections in adults; Post-exposure inhalational anthrax and source-specified plague treatment/prevention in adults and children · Common side effects — Nausea; Abnormal liver function tests; Vomiting; Rash · Warnings — QT prolongation; C. difficile-associated diarrhea · Interactions — Tizanidine (contraindicated); Theophylline; Other CYP1A2 substrates
Mechanism: Fluoroquinolone antibacterial active against designated susceptible bacteria.
On both cards: Common side effects — Diarrhea · Warnings — Hepatotoxicity
Only on the Levofloxacin card: Used for — Adult nosocomial or community-acquired pneumonia caused by the specified susceptible organisms; Adult complicated UTI; uncomplicated UTI only when no alternative treatment options exist; Adult acute bacterial sinusitis only when no alternative treatment options exist; Post-exposure inhalational anthrax and treatment/prophylaxis of plague in adults and children aged 6 months or older; pediatric formulation/weight restrictions apply · Common side effects — Nausea; Headache; Insomnia; Dizziness · Warnings — QT prolongation; C. difficile-associated diarrhea · Interactions — Antacids / multivalent cations; Warfarin; Antidiabetic agents
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Capsera