Emtricitabine / Tenofovir Disoproxil Fumarate: study card

Emtricitabine / Tenofovir Disoproxil Fumarate — NRTI combination (HIV-1). Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Emtricitabine / Tenofovir Disoproxil Fumarate
Class
NRTI combination (HIV-1)
Mechanism
Fixed-dose HIV-1 reverse-transcriptase inhibitor combination: emtricitabine is a nucleoside analog; tenofovir disoproxil fumarate is converted to the nucleotide analog tenofovir.
Used for
HIV-1 treatment with other antiretrovirals in adults and children weighing at least 17 kg; PrEP to reduce sexually acquired HIV-1 risk in at-risk adults and adolescents weighing at least 35 kg, with a negative HIV-1 test immediately before initiation
Common side effects
Diarrhea; Nausea; Fatigue; Headache; Dizziness
Boxed warning
Stopping treatment can cause severe hepatitis B exacerbations in people infected with HBV. For HIV PrEP, confirm HIV-negative status immediately before starting and at least every 3 months during use; resistant HIV can emerge when acute infection is undetected.
Warnings
New or worsening renal impairment; Decreased bone mineral density; Lactic acidosis, severe hepatomegaly
Interactions
Didanosine; Atazanavir; Some HIV protease inhibitors, HCV drugs

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260805 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Emtricitabine: em-trye-SYE-ta-been · Tenofovir Disoproxil Fumarate: te-NOE-fo-veer

Pronunciation is shown for the US English generic name.

Body system

Infectious disease · 21 Drug cards

Compare with related cards

Levofloxacin

Same body system: Infectious disease

Mechanism: Fluoroquinolone antibacterial active against designated susceptible bacteria.

On both cards: Common side effects — Diarrhea; Nausea; Headache; Dizziness

Only on the Levofloxacin card: Used for — Adult nosocomial or community-acquired pneumonia caused by the specified susceptible organisms; Adult complicated UTI; uncomplicated UTI only when no alternative treatment options exist; Adult acute bacterial sinusitis only when no alternative treatment options exist; Post-exposure inhalational anthrax and treatment/prophylaxis of plague in adults and children aged 6 months or older; pediatric formulation/weight restrictions apply · Common side effects — Insomnia · Warnings — QT prolongation; Hepatotoxicity; C. difficile-associated diarrhea · Interactions — Antacids / multivalent cations; Warfarin; Antidiabetic agents

Cefdinir

Same body system: Infectious disease

Mechanism: Cephalosporin (beta-lactam) antibacterial; inhibits bacterial cell wall synthesis.

On both cards: Common side effects — Diarrhea; Nausea; Headache

Only on the Cefdinir card: Used for — Mild-to-moderate community-acquired pneumonia due to specified susceptible bacteria in adults and adolescents; Acute exacerbations of chronic bronchitis due to specified susceptible bacteria in adults and adolescents; Acute maxillary sinusitis due to specified susceptible bacteria; pediatric use is addressed in the source-specific dosing section; Streptococcus pyogenes pharyngitis or tonsillitis in the adult/adolescent and pediatric populations specified by the label · Common side effects — Vaginal moniliasis; Abdominal pain · Warnings — Cephalosporin hypersensitivity is a contraindication; serious cross-allergic reactions can occur; C. difficile-associated diarrhea may progress to severe or fatal colitis · Interactions — Aluminum / magnesium antacids; Iron supplements; Probenecid

Fluconazole

Same body system: Infectious disease

Mechanism: Selectively inhibits fungal CYP450 lanosterol 14-alpha-demethylase, blocking ergosterol synthesis (fungistatic).

On both cards: Common side effects — Diarrhea; Nausea; Headache

Only on the Fluconazole card: Used for — Vaginal candidiasis; Oropharyngeal and esophageal candidiasis; Cryptococcal meningitis; Reduction of candidiasis in bone-marrow transplant patients receiving cytotoxic chemotherapy and/or radiation therapy · Common side effects — Abdominal pain; Dyspepsia · Warnings — Hypersensitivity; caution with other azole allergy; Contraindicated with QT-prolonging CYP3A4 substrates; Rare serious liver injury, including fatal cases, and severe exfoliative skin reactions have been reported; Pregnancy exposure requires risk review: high-dose first-trimester exposure has been associated with a distinct birth-defect pattern; lower-dose observational signals have important limitations · Interactions — Erythromycin; Pimozide; Quinidine

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Other cards with a boxed warning in this body system (Infectious disease): Nirmatrelvir / Ritonavir, Ciprofloxacin, Clindamycin phosphate, Metronidazole (oral), Levofloxacin