MAO inhibitors (contraindicated); Other serotonergic drugs; Aspirin, NSAIDs, anticoagulants
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260724 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Exact mechanism unknown; believed to potentiate serotonergic and noradrenergic activity in the CNS.
On both cards: Common side effects — Nausea; Hyperhidrosis; Constipation · Warnings — Serotonin syndrome
Only on the Duloxetine card: Used for — Major depressive disorder in adults; Generalized anxiety disorder in adults and children aged 7 years and older; Diabetic peripheral neuropathic pain in adults; Fibromyalgia in adults and adolescents aged 13 years and older; Chronic musculoskeletal pain in adults · Common side effects — Dry mouth; Somnolence · Warnings — Hepatotoxicity; Orthostatic hypotension, falls, syncope · Interactions — Potent CYP1A2 inhibitors; Potent CYP2D6 inhibitors; MAOIs
Mechanism: Thought to potentiate serotonin and norepinephrine in the CNS by inhibiting their reuptake.
On both cards: Common side effects — Nausea · Warnings — Serotonin syndrome; Elevated blood pressure · Interactions — Other serotonergic drugs
Only on the Venlafaxine card: Used for — Major depressive disorder in adults; Generalized anxiety disorder in adults; Social anxiety disorder in adults; Panic disorder in adults · Common side effects — Somnolence; Dry mouth; Sweating; Abnormal ejaculation · Warnings — Discontinuation syndrome · Interactions — MAO inhibitors; Antiplatelets / anticoagulants
Mechanism: Potentiates serotonergic activity in the CNS by inhibiting neuronal reuptake of serotonin (5-HT).
On both cards: Common side effects — Nausea; Hyperhidrosis · Warnings — Serotonin syndrome
Only on the Sertraline card: Used for — Major depressive disorder in adults; Obsessive-compulsive disorder in adults and children aged 6–17 years; Panic disorder, PTSD or social anxiety disorder in adults; Premenstrual dysphoric disorder in adults · Common side effects — Diarrhea / loose stool; Tremor; Ejaculation failure · Warnings — Increased risk of bleeding; Activation of mania / hypomania · Interactions — MAOIs (incl. linezolid, IV methylene blue); Pimozide; Warfarin and other protein-bound drugs
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Boxed warnings on related cards
Duloxetine: Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents and young adults.
Venlafaxine: Antidepressants increased suicidal thoughts and behaviors in pediatric and young adult patients; not approved in children.
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