CapseraSerotonin-norepinephrine reuptake inhibitors
Compare the named medicines in this source-linked class directory.
Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.
No matching drugs. Try another name.
Generic names and pronunciation
| Duloxetine · doo-LOX-e-teen |
| Venlafaxine · ven-la-FAX-een |
| Desvenlafaxine · des-VEN-la-fax-een |
Pronunciation is shown for the US English generic name.
Body system and related classes
Body system: Psychiatry
How each medicine works
| Duloxetine — Exact mechanism unknown; believed to potentiate serotonergic and noradrenergic activity in the CNS. |
| Venlafaxine — Thought to potentiate serotonin and norepinephrine in the CNS by inhibiting their reuptake. |
| Desvenlafaxine — Thought to potentiate serotonin and norepinephrine in the CNS by inhibiting their reuptake; a potent, selective SNRI. |
Each summary is the mechanism line from the medicine’s study card.
What each medicine is used for
| Duloxetine — Major depressive disorder in adults; Generalized anxiety disorder in adults and children aged 7 years and older; Diabetic peripheral neuropathic pain in adults; Fibromyalgia in adults and adolescents aged 13 years and older; Chronic musculoskeletal pain in adults |
| Venlafaxine — Major depressive disorder in adults; Generalized anxiety disorder in adults; Social anxiety disorder in adults; Panic disorder in adults |
| Desvenlafaxine — Major depressive disorder (adults) |
Each list is the uses line from the medicine’s study card.
Telling these medicines apart
Medicines in this class: 3
Listed on more than one card in this class
Used for
Major depressive disorder in adults · 2/3: Duloxetine, Venlafaxine
Common side effects
Nausea · 3/3: Duloxetine, Venlafaxine, Desvenlafaxine
Dry mouth · 2/3: Duloxetine, Venlafaxine
Somnolence · 2/3: Duloxetine, Venlafaxine
Constipation · 2/3: Duloxetine, Desvenlafaxine
Hyperhidrosis · 2/3: Duloxetine, Desvenlafaxine
Warnings
Serotonin syndrome · 3/3: Duloxetine, Venlafaxine, Desvenlafaxine
Elevated blood pressure · 2/3: Venlafaxine, Desvenlafaxine
Interactions
Other serotonergic drugs · 2/3: Venlafaxine, Desvenlafaxine
Boxed warning
3/3: Duloxetine, Venlafaxine, Desvenlafaxine
Listed on only one card in this class
Duloxetine: Warnings — Hepatotoxicity; Orthostatic hypotension, falls, syncope · Interactions — Potent CYP1A2 inhibitors; Potent CYP2D6 inhibitors; MAOIs
Venlafaxine: Common side effects — Sweating; Abnormal ejaculation · Warnings — Discontinuation syndrome · Interactions — MAO inhibitors; Antiplatelets / anticoagulants
Desvenlafaxine: Common side effects — Dizziness; Insomnia · Warnings — Increased bleeding risk · Interactions — MAO inhibitors (contraindicated); Aspirin, NSAIDs, anticoagulants
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.