CapseraDPP-4 inhibitors
Compare the named medicines in this source-linked class directory.
Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.
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Generic names and pronunciation
Shared name ending: -gliptin · Sitagliptin, Linagliptin
| Sitagliptin · sit-a-GLIP-tin |
| Linagliptin · lin-a-GLIP-tin |
Pronunciation is shown for the US English generic name. A name ending is a memory cue, not a classification rule.
Body system and related classes
Body system: Endocrine
How each medicine works
| Sitagliptin — A DPP-4 inhibitor believed to act by slowing incretin inactivation. It increases and prolongs active GLP-1 and GIP levels, which influence insulin and glucagon in a glucose-dependent manner. |
| Linagliptin — Inhibits DPP-4, raising active GLP-1 and GIP; increases glucose-dependent insulin release and lowers glucagon. |
Each summary is the mechanism line from the medicine’s study card.
What each medicine is used for
| Sitagliptin — Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes |
| Linagliptin — Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes |
Each list is the uses line from the medicine’s study card.
Telling these medicines apart
Medicines in this class: 2
Listed on more than one card in this class
Common side effects
Nasopharyngitis · 2/2: Sitagliptin, Linagliptin
Warnings
Pancreatitis · 2/2: Sitagliptin, Linagliptin
Listed on only one card in this class
Sitagliptin: Common side effects — Upper respiratory tract infection; Headache · Warnings — Heart failure; Acute renal failure · Interactions — Insulin or insulin secretagogues (sulfonylureas)
Linagliptin: Common side effects — Hypoglycemia with insulin or secretagogues · Warnings — Severe, disabling arthralgia; Bullous pemphigoid · Interactions — Strong P-gp/CYP3A4 inducers (e.g., rifampin); Insulin and insulin secretagogues
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.