Insulins

Compare the named medicines in this source-linked class directory.

Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.

Insulin glargineBasaglar
Insulin LisproAdmelog
Insulin Aspart
Insulin degludecTresiba
Insulin detemirLevemir
Insulin Isophane / Insulin Regular (human)Humulin 70/30

Combination: membership refers to the relevant component.

Generic names and pronunciation

Insulin glargine · IN-su-lin GLAR-jeen
Insulin Lispro · IN-su-lin LYE-sproe
Insulin Aspart · IN-su-lin AS-part
Insulin degludec · IN-su-lin DEG-loo-dek
Insulin detemir · IN-su-lin DE-te-mir
Insulin Isophane · IN-su-lin EYE-soe-fane
Insulin Regular (human) · IN-su-lin REG-yoo-lar

Pronunciation is shown for the US English generic name.

Body system and related classes

Body system: Endocrine

How each medicine works

Insulin glargine — Regulates glucose metabolism: stimulates peripheral glucose uptake (muscle, fat) and inhibits hepatic glucose production.
Insulin Lispro — Lowers blood glucose by stimulating peripheral glucose uptake in muscle and fat and inhibiting hepatic glucose production.
Insulin Aspart — Regulates glucose metabolism: stimulates peripheral glucose uptake in muscle and fat and inhibits hepatic glucose production.
Insulin degludec — Lowers glucose by stimulating peripheral uptake and inhibiting hepatic output; forms multi-hexamers in subcutaneous tissue.
Insulin detemir — Regulates glucose metabolism: stimulates peripheral glucose uptake and inhibits hepatic glucose production, lipolysis, proteolysis.
Insulin Isophane / Insulin Regular (human) — Stimulates glucose uptake in skeletal muscle and fat and inhibits hepatic glucose production; pairs intermediate-acting insulin with faster-onset regular insulin.

Each summary is the mechanism line from the medicine’s study card.

What each medicine is used for

Insulin glargine — Glycemic control in adults and children aged 6 years and older with type 1 diabetes mellitus; Glycemic control in adults with type 2 diabetes mellitus
Insulin Lispro — Glycemic control in adults and pediatric patients with diabetes mellitus
Insulin Aspart — Glycemic control in adults and pediatric patients with diabetes mellitus
Insulin degludec — Glycemic control in diabetes mellitus from age 1 year
Insulin detemir — Glycemic control in adults and pediatric patients with diabetes mellitus
Insulin Isophane / Insulin Regular (human) — Diabetes mellitus in adults (glycemic control)

Each list is the uses line from the medicine’s study card.

Telling these medicines apart

Medicines in this class: 6 · single-ingredient: 5 · combination products: 1

Listed on more than one card in this class

Used for

Glycemic control in adults and pediatric patients with diabetes mellitus · 3/6: Insulin Lispro, Insulin Aspart, Insulin detemir

Common side effects

Hypoglycemia · 6/6: Insulin glargine, Insulin Lispro, Insulin Aspart, Insulin degludec, Insulin detemir, Insulin Isophane / Insulin Regular (human)

Lipodystrophy · 6/6: Insulin glargine, Insulin Lispro, Insulin Aspart, Insulin degludec, Insulin detemir, Insulin Isophane / Insulin Regular (human)

Injection site reactions · 5/6: Insulin Lispro, Insulin Aspart, Insulin degludec, Insulin detemir, Insulin Isophane / Insulin Regular (human)

Allergic reactions · 4/6: Insulin Lispro, Insulin Aspart, Insulin degludec, Insulin detemir

Weight gain · 3/6: Insulin glargine, Insulin degludec, Insulin Isophane / Insulin Regular (human)

Edema · 2/6: Insulin glargine, Insulin Isophane / Insulin Regular (human)

Rash · 2/6: Insulin Lispro, Insulin Aspart

Warnings

Hypokalemia · 6/6: Insulin glargine, Insulin Lispro, Insulin Aspart, Insulin degludec, Insulin detemir, Insulin Isophane / Insulin Regular (human)

Hypoglycemia · 3/6: Insulin glargine, Insulin Lispro, Insulin Aspart

Hypoglycemia, may be life-threatening · 3/6: Insulin degludec, Insulin detemir, Insulin Isophane / Insulin Regular (human)

Never share pens or syringes · 2/6: Insulin Lispro, Insulin Isophane / Insulin Regular (human)

Never share pens or needles · 2/6: Insulin degludec, Insulin detemir

Interactions

Antidiabetic agents, ACE inhibitors, ARBs · 4/6: Insulin glargine, Insulin Lispro, Insulin Aspart, Insulin Isophane / Insulin Regular (human)

Fibrates, fluoxetine, MAOIs · 2/6: Insulin Lispro, Insulin Aspart

Other antidiabetic agents · 2/6: Insulin degludec, Insulin detemir

ACE inhibitors / ARBs · 2/6: Insulin degludec, Insulin detemir

Fluoxetine, MAOIs, salicylates · 2/6: Insulin degludec, Insulin detemir

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.