Sitagliptin — DPP-4 inhibitor (gliptin). Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Sitagliptin
Class
DPP-4 inhibitor (gliptin)
Mechanism
A DPP-4 inhibitor believed to act by slowing incretin inactivation. It increases and prolongs active GLP-1 and GIP levels, which influence insulin and glucagon in a glucose-dependent manner.
Used for
Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260812 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Inhibits DPP-4, raising active GLP-1 and GIP; increases glucose-dependent insulin release and lowers glucagon.
On both cards: Common side effects — Nasopharyngitis · Warnings — Pancreatitis
Only on the Linagliptin card: Used for — Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes · Common side effects — Hypoglycemia with insulin or secretagogues · Warnings — Severe, disabling arthralgia; Bullous pemphigoid · Interactions — Strong P-gp/CYP3A4 inducers (e.g., rifampin); Insulin and insulin secretagogues
Mechanism: PPAR-gamma agonist that decreases insulin resistance in periphery and liver; requires insulin, not a secretagogue.
On both cards: Common side effects — Upper respiratory tract infection; Headache
Only on the Pioglitazone card: Used for — Type 2 diabetes in adults, as an adjunct to diet and exercise · Common side effects — Sinusitis; Myalgia; Pharyngitis · Warnings — Hepatic failure (postmarketing); Bladder cancer; Edema and fractures · Interactions — Strong CYP2C8 inhibitors (e.g., gemfibrozil); CYP2C8 inducers (e.g., rifampin); Topiramate
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
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