Pioglitazone: study card

Pioglitazone — Thiazolidinedione (PPAR-gamma agonist). Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Pioglitazone
Class
Thiazolidinedione (PPAR-gamma agonist)
Mechanism
PPAR-gamma agonist that decreases insulin resistance in periphery and liver; requires insulin, not a secretagogue.
Used for
Type 2 diabetes in adults, as an adjunct to diet and exercise
Common side effects
Upper respiratory tract infection; Headache; Sinusitis; Myalgia; Pharyngitis
Boxed warning
Thiazolidinediones cause or worsen congestive heart failure; do not start in NYHA class III or IV heart failure.
Warnings
Hepatic failure (postmarketing); Bladder cancer; Edema and fractures
Interactions
Strong CYP2C8 inhibitors (e.g., gemfibrozil); CYP2C8 inducers (e.g., rifampin); Topiramate

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260827 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Pioglitazone: pye-oh-GLI-ta-zone

Pronunciation is shown for the US English generic name.

Body system

Endocrine · 27 Drug cards

Compare with related cards

Glimepiride

Same body system: Endocrine

Mechanism: Binds beta-cell sulfonylurea receptors, closing ATP-sensitive K+ channels and stimulating insulin release.

On both cards: Used for — Type 2 diabetes in adults, as an adjunct to diet and exercise · Common side effects — Headache

Only on the Glimepiride card: Common side effects — Hypoglycemia; Nausea; Dizziness; Asthenia · Warnings — Severe hypoglycemia; Hypersensitivity incl. sulfonamide allergy; Hemolytic anemia in G6PD deficiency · Interactions — Oral miconazole (severe hypoglycemia); CYP2C9 inhibitors and inducers; Colesevelam

Sitagliptin

Same body system: Endocrine

Mechanism: A DPP-4 inhibitor believed to act by slowing incretin inactivation. It increases and prolongs active GLP-1 and GIP levels, which influence insulin and glucagon in a glucose-dependent manner.

On both cards: Common side effects — Upper respiratory tract infection; Headache

Only on the Sitagliptin card: Used for — Adjunct to diet and exercise for glycemic control in adults with type 2 diabetes · Common side effects — Nasopharyngitis · Warnings — Pancreatitis; Heart failure; Acute renal failure · Interactions — Insulin or insulin secretagogues (sulfonylureas)

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Other cards with a boxed warning in this body system (Endocrine): Metformin, Levothyroxine, Semaglutide, Dulaglutide, Testosterone, Tirzepatide, Liraglutide, Liothyronine