Antidepressants increased suicidal thinking and behavior in children, adolescents and young adults.
Warnings
Psychiatric MAOIs are contraindicated with nortriptyline and within 14 days of switching in either direction; Do not start nortriptyline in a patient receiving linezolid or intravenous methylene blue because of serotonin-syndrome risk
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260903 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Inhibits norepinephrine and serotonin uptake in adrenergic and serotonergic neurons. Its mechanism of antidepressant action in humans is not known; reuptake inhibition is a proposed explanation.
On both cards: Common side effects — Dry mouth; Blurred vision; Constipation; Urinary retention · Interactions — CYP2D6 inhibitors
Only on the Amitriptyline card: Used for — Depression · Common side effects — Orthostatic hypotension · Warnings — Concomitant MAOIs (contraindicated); Cisapride (QT prolongation risk); Acute recovery phase after MI · Interactions — MAOIs; Topiramate
Mechanism: Exact mechanism unknown; believed to potentiate serotonergic and noradrenergic activity in the CNS.
On both cards: Common side effects — Dry mouth; Constipation
Only on the Duloxetine card: Used for — Major depressive disorder in adults; Generalized anxiety disorder in adults and children aged 7 years and older; Diabetic peripheral neuropathic pain in adults; Fibromyalgia in adults and adolescents aged 13 years and older; Chronic musculoskeletal pain in adults · Common side effects — Nausea; Somnolence; Hyperhidrosis · Warnings — Hepatotoxicity; Orthostatic hypotension, falls, syncope; Serotonin syndrome · Interactions — Potent CYP1A2 inhibitors; Potent CYP2D6 inhibitors; MAOIs
Mechanism: Mechanism unclear; efficacy may be mediated by combined dopamine D2 and serotonin 5-HT2 receptor antagonism.
On both cards: Common side effects — Dry mouth; Constipation
Only on the Quetiapine card: Used for — Schizophrenia in adults and adolescents aged 13 years and older; Acute bipolar I mania as monotherapy in adults and children aged 10 years and older, or as adjunct to lithium/divalproex in adults; Acute bipolar depressive episodes as monotherapy in adults · Common side effects — Somnolence; Dizziness; Weight gain · Warnings — Neuroleptic malignant syndrome; Hyperglycemia, dyslipidemia, weight gain; Cerebrovascular events in elderly dementia · Interactions — Strong CYP3A4 inhibitors (ketoconazole, ritonavir); Strong CYP3A4 inducers (phenytoin, rifampin)
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Capsera