Linaclotide — Guanylate cyclase-C agonist. Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Linaclotide
Brands
Linzess
Class
Guanylate cyclase-C agonist
Mechanism
Binds GC-C on the intestinal lumen, raising cGMP; increases intestinal fluid secretion and transit.
Used for
IBS with constipation in adults and children aged 7 or older; Chronic idiopathic constipation in adults; Functional constipation in children aged 2 or older
Label date: 20261009 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Substituted benzimidazole that inhibits the H+/K+ ATPase (proton pump) of the gastric parietal cell, blocking the final step of acid secretion.
On both cards: Common side effects — Diarrhea; Abdominal pain; Flatulence
Only on the Omeprazole card: Used for — Short-term treatment of active duodenal or benign gastric ulcer in adults; H. pylori eradication with the specified antibiotics in adults with duodenal ulcer disease; Short-term symptomatic GERD or erosive esophagitis treatment, and maintenance of healed erosive esophagitis, in patients aged 2 years and older; Long-term treatment of pathological hypersecretory conditions in adults · Common side effects — Headache; Nausea · Warnings — Acute tubulointerstitial nephritis; C. difficile-associated diarrhea; Bone fracture with long-term use
Mechanism: Converted in the parietal cell to an active inhibitor that blocks the H+/K+ ATPase (proton pump), suppressing gastric acid secretion.
On both cards: Common side effects — Diarrhea; Abdominal pain; Flatulence
Only on the Esomeprazole magnesium card: Used for — Short-term erosive-esophagitis healing in adults and ages 12–17; maintenance of healing in adults; Short-term heartburn and other GERD symptoms in adults and ages 12–17; Reduce NSAID-associated gastric-ulcer risk in adults receiving continuous NSAIDs who are aged 60 or older and/or have a documented gastric-ulcer history; With amoxicillin and clarithromycin, eradicate H. pylori in adults with active duodenal ulcer or a history within 5 years to reduce recurrence · Common side effects — Headache; Nausea · Warnings — C. difficile-associated diarrhea; Bone fracture with long-term use; Acute tubulointerstitial nephritis
Mechanism: Covalently binds the H+/K+ ATPase of the gastric parietal cell, suppressing the final step of acid production, basal and stimulated.
On both cards: Common side effects — Diarrhea; Abdominal pain
Only on the Pantoprazole card: Used for — Short-term healing and symptom relief of GERD-associated erosive esophagitis in adults and children aged 5 years and older; Maintenance of healed erosive esophagitis and reduction of heartburn relapse in adults with GERD; Long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, in adults · Common side effects — Headache; Nausea · Warnings — C. difficile-associated diarrhea; Bone fracture with long-term use; Vitamin B12 deficiency
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Capsera