Alendronate — Bisphosphonate. Study the mechanism, listed uses and warnings from the US label on one sourced card.
Generic name
Alendronate
Class
Bisphosphonate
Mechanism
Animal studies show preferential localization at bone-resorption sites beneath osteoclasts and inhibition of osteoclast activity, reducing bone resorption.
Used for
Treatment and prevention of postmenopausal osteoporosis; Increase of bone mass in men with osteoporosis; Glucocorticoid-induced osteoporosis with low bone mineral density in men/women taking at least 7.5 mg/day prednisone-equivalent; Paget disease in men/women with alkaline phosphatase at least twice the upper limit of normal, symptoms or risk of future complications
Upper GI irritation (must stay upright); Osteonecrosis of the jaw; Atypical femoral fractures
Interactions
Calcium supplements / antacids; Aspirin / NSAIDs
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260703 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Shows anti-inflammatory, analgesic and antipyretic activity in animal models. Its mechanism is not completely understood and may involve prostaglandin-synthetase inhibition.
On both cards: Common side effects — Abdominal pain; Dyspepsia; Nausea
Only on the Etodolac card: Used for — Signs and symptoms of osteoarthritis or rheumatoid arthritis in adults; Acute pain in adults · Common side effects — Diarrhea; Dizziness · Warnings — Asthma or allergy after aspirin/other NSAIDs; New or worsening hypertension, heart failure; Hepatic reactions, elevated liver tests · Interactions — Warfarin (synergistic GI bleeding); ACE inhibitors, thiazide and loop diuretics; Lithium, methotrexate, cyclosporine, digoxin
Mechanism: Mechanism is incompletely understood but involves COX-1 and COX-2 inhibition; reduced prostaglandin synthesis may contribute to its peripheral effects.
On both cards: Common side effects — Dyspepsia; Nausea
Only on the Indomethacin card: Used for — Moderate-to-severe rheumatoid arthritis, including acute flares; Moderate-to-severe ankylosing spondylitis; Moderate-to-severe osteoarthritis; Acute painful shoulder caused by bursitis and/or tendinitis · Common side effects — Headache; Dizziness · Warnings — Hepatotoxicity; Heart failure and edema; Renal toxicity · Interactions — Anticoagulants (e.g., warfarin); Aspirin and antiplatelets; SSRIs and SNRIs
Mechanism: Prodrug converted in the liver to 6MNA, a potent inhibitor of prostaglandin synthesis.
On both cards: Common side effects — Abdominal pain; Dyspepsia
Only on the Nabumetone card: Used for — Relief of osteoarthritis signs and symptoms in adults; Relief of rheumatoid arthritis signs and symptoms in adults · Common side effects — Diarrhea; Constipation; Flatulence · Warnings — Contraindicated in CABG setting; Aspirin/NSAID-induced asthma or urticaria · Interactions — ACE inhibitors; Diuretics (furosemide, thiazides); Lithium
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.
Capsera