CapseraDirect factor Xa inhibitors
Compare the named medicines in this source-linked class directory.
Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.
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Generic names and pronunciation
Shared name ending: -xaban · Apixaban, Rivaroxaban
| Apixaban · a-PIX-a-ban |
| Rivaroxaban · riv-a-ROX-a-ban |
Pronunciation is shown for the US English generic name. A name ending is a memory cue, not a classification rule.
Body system and related classes
Body system: Hematology
How each medicine works
| Apixaban — Selective inhibitor of free and clot-bound factor Xa and prothrombinase, independent of antithrombin III; decreases thrombin generation. |
| Rivaroxaban — Selectively inhibits free factor Xa and prothrombinase activity without antithrombin, decreasing thrombin generation. |
Each summary is the mechanism line from the medicine’s study card.
What each medicine is used for
| Apixaban — Stroke and systemic-embolism risk reduction in adults with nonvalvular atrial fibrillation; DVT prophylaxis after hip or knee replacement in adults; Treatment of DVT or pulmonary embolism in adults; Reduction of recurrent DVT or pulmonary embolism risk in adults after initial therapy |
| Rivaroxaban — Stroke and systemic-embolism risk reduction in adults with nonvalvular atrial fibrillation; Treatment of DVT or PE in adults; pediatric VTE treatment/recurrent-risk reduction is separately indicated after at least 5 days of initial parenteral anticoagulation; DVT prophylaxis in adults after hip or knee replacement; Reduction of major cardiovascular events in adults with coronary artery disease, in combination with aspirin; Reduction of major thrombotic vascular events in adults with peripheral artery disease, in combination with aspirin |
Each list is the uses line from the medicine’s study card.
Telling these medicines apart
Medicines in this class: 2
Listed on more than one card in this class
Used for
Stroke and systemic-embolism risk reduction in adults with nonvalvular atrial fibrillation · 2/2: Apixaban, Rivaroxaban
Common side effects
Bleeding · 2/2: Apixaban, Rivaroxaban
Vomiting (pediatric) · 2/2: Apixaban, Rivaroxaban
Warnings
Triple-positive antiphospholipid syndrome · 2/2: Apixaban, Rivaroxaban
Boxed warning
2/2: Apixaban, Rivaroxaban
Listed on only one card in this class
Apixaban: Common side effects — Headache (pediatric); Excessive menstrual bleeding (pediatric) · Warnings — Serious, potentially fatal bleeding; Not recommended with prosthetic heart valves · Interactions — Combined P-gp and strong CYP3A4 inhibitors; Combined P-gp and strong CYP3A4 inducers; Aspirin, NSAIDs, antiplatelets
Rivaroxaban: Common side effects — Cough (pediatric); Gastroenteritis (pediatric) · Warnings — Serious and fatal bleeding; Prosthetic heart valves: not recommended · Interactions — Combined P-gp and strong CYP3A inhibitors; Combined P-gp and strong CYP3A inducers; Other anticoagulants
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.