Rivaroxaban: brand names and study card

Rivaroxaban — Factor Xa inhibitor (DOAC). Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name: Rivaroxaban
Brands: Xarelto
Class: Factor Xa inhibitor (DOAC)
Mechanism: Selectively inhibits free factor Xa and prothrombinase activity without antithrombin, decreasing thrombin generation.
Used for: Stroke and systemic-embolism risk reduction in adults with nonvalvular atrial fibrillation; Treatment of DVT or PE in adults; pediatric VTE treatment/recurrent-risk reduction is separately indicated after at least 5 days of initial parenteral anticoagulation; DVT prophylaxis in adults after hip or knee replacement; Reduction of major cardiovascular events in adults with coronary artery disease, in combination with aspirin; Reduction of major thrombotic vascular events in adults with peripheral artery disease, in combination with aspirin
Common side effects: Bleeding; Cough (pediatric); Vomiting (pediatric); Gastroenteritis (pediatric)
Boxed warning: Premature discontinuation increases thrombotic risk; spinal/epidural hematoma with neuraxial anesthesia or puncture.
Warnings: Serious and fatal bleeding; Prosthetic heart valves: not recommended; Triple-positive antiphospholipid syndrome
Interactions: Combined P-gp and strong CYP3A inhibitors; Combined P-gp and strong CYP3A inducers; Other anticoagulants

Drug class families: Direct factor Xa inhibitors

Read the source label ↗

Label date: 20260910 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Practice

Pronunciation

Rivaroxaban: riv-a-ROX-a-ban

Shared name ending: -xaban · Apixaban

Pronunciation is shown for the US English generic name. A name ending is a memory cue, not a classification rule.

Other drugs in the same class

Direct factor Xa inhibitors: Apixaban

Body system

Hematology · 7 Drug cards

Compare with related cards

Apixaban

Same class family: Direct factor Xa inhibitors

Mechanism: Selective inhibitor of free and clot-bound factor Xa and prothrombinase, independent of antithrombin III; decreases thrombin generation.

On both cards: Used for — Stroke and systemic-embolism risk reduction in adults with nonvalvular atrial fibrillation · Common side effects — Bleeding; Vomiting (pediatric) · Warnings — Triple-positive antiphospholipid syndrome

Only on the Apixaban card: Used for — DVT prophylaxis after hip or knee replacement in adults; Treatment of DVT or pulmonary embolism in adults; Reduction of recurrent DVT or pulmonary embolism risk in adults after initial therapy · Common side effects — Headache (pediatric); Excessive menstrual bleeding (pediatric) · Warnings — Serious, potentially fatal bleeding; Not recommended with prosthetic heart valves · Interactions — Combined P-gp and strong CYP3A4 inhibitors; Combined P-gp and strong CYP3A4 inducers; Aspirin, NSAIDs, antiplatelets

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.

Boxed warnings on related cards

Apixaban: Premature discontinuation raises thrombotic risk; spinal/epidural hematoma may occur with neuraxial anesthesia or puncture.