- Generic name
- Warfarin
- Class
- Vitamin K antagonist anticoagulant
- Mechanism
- Inhibits synthesis of vitamin K-dependent clotting factors II, VII, IX and X and anticoagulant proteins C and S.
- Used for
- Venous thrombosis and PE (prevent / treat); Thromboembolism with AF or valve replacement; Reduce death, reinfarction and stroke after MI
- Common side effects
- Hemorrhage; Hypersensitivity reactions; Elevated liver enzymes; Vasculitis
- Boxed warning
- Can cause major or fatal bleeding; monitor INR regularly; drugs and diet affect INR.
- Warnings
- Tissue necrosis; Calciphylaxis; Pregnancy is contraindicated except in pregnant women with mechanical heart valves at high risk of thromboembolism
- Interactions
- Drugs that increase bleeding risk; Antibiotics and antifungals; CYP2C9, 1A2 or 3A4 inhibitors / inducers
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Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.