Liothyronine: study card

Generic name

Liothyronine

Class

Thyroid hormone (T3)

Mechanism

T3 binds nuclear thyroid receptors on DNA, activating gene transcription and protein synthesis.

Used for

Replacement therapy for congenital or acquired primary, secondary or tertiary hypothyroidism; TSH suppression as an adjunct to surgery and radioiodine for well-differentiated thyroid cancer; Diagnostic suppression testing to distinguish suspected mild hyperthyroidism or thyroid autonomy

Common side effects

Arrhythmias; Nervousness; Insomnia; Tremors; Weight loss

Boxed warning

Not for treatment of obesity or for weight loss.

Warnings

Cardiac adverse reactions in older patients and those with cardiovascular disease; Uncorrected adrenal insufficiency is contraindicated; Oral thyroid hormone products should not be used for myxedema coma

Interactions

Bile acid sequestrants; Ion exchange resins

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Label date: 20260604 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.