Hypersensitivity to methocarbamol; Alcohol and other CNS depressants can add to sedating effects; Mental or physical ability for driving and hazardous tasks may be impaired; Pregnancy use requires a clinician's benefit-risk assessment
Interactions
CNS depressants and alcohol; Pyridostigmine (myasthenia gravis)
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20260827 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: Relieves skeletal muscle spasm of local origin without interfering with muscle function. Animal studies support a mainly central action rather than a direct action at skeletal muscle or the neuromuscular junction.
Only on the Cyclobenzaprine card: Used for — Short-term relief of muscle spasm from acute, painful musculoskeletal conditions, as an adjunct to rest and physical therapy · Common side effects — Dry mouth; Dizziness; Fatigue; Constipation; Somnolence · Warnings — Serotonin syndrome; TCA-like cardiovascular / CNS effects; Not recommended in elderly or hepatic impairment; The selected extended-release capsule is intended only for short periods, up to 2–3 weeks; effectiveness for central spasticity has not been established · Interactions — MAO inhibitors; Alcohol, barbiturates, CNS depressants; Tramadol
Mechanism: The precise mechanism is not fully known. Baclofen can inhibit monosynaptic and polysynaptic spinal reflexes, possibly by hyperpolarizing afferent terminals; supraspinal actions may also contribute.
On both cards: Common side effects — Drowsiness · Interactions — CNS depressants and alcohol
Only on the Baclofen card: Used for — Alleviation of reversible spasticity due to multiple sclerosis; May also be of value for patients with spinal cord injuries or other spinal cord diseases · Common side effects — Dizziness; Weakness; Fatigue · Warnings — Abrupt withdrawal: hallucinations, seizures; Neonatal withdrawal if used in pregnancy; Not for rheumatic muscle spasm
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.