Doxepin: study card

Doxepin — Tricyclic (H1 antagonist) hypnotic. Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Doxepin
Class
Tricyclic (H1 antagonist) hypnotic
Mechanism
Mechanism in sleep maintenance unclear; effect may be mediated through H1 receptor antagonism.
Used for
Insomnia characterized by difficulty maintaining sleep in adults, for the cited low-dose tablets
Common side effects
Somnolence / sedation; Nausea; Upper respiratory tract infection
Warnings
Complex sleep behaviors (sleep-driving); Worsening depression / suicidal thinking; CNS depression
Interactions
MAO inhibitors; Cimetidine; Alcohol / CNS depressants

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260904 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Doxepin: DOX-e-pin

Pronunciation is shown for the US English generic name.

Body system

Psychiatry · 30 Drug cards

Compare with related cards

Buspirone

Same body system: Psychiatry

Mechanism: Mechanism is unknown. Preclinical studies show high 5-HT1A receptor affinity; buspirone also has moderate D2 affinity, no significant benzodiazepine-receptor affinity and no effect on GABA binding in the tested preclinical models.

On both cards: Common side effects — Nausea · Interactions — MAO inhibitors

Only on the Buspirone card: Used for — Anxiety disorders; Short-term relief of anxiety symptoms · Common side effects — Dizziness; Headache; Nervousness; Lightheadedness · Warnings — Contraindicated with MAOIs (serotonin syndrome); Hypersensitivity to buspirone · Interactions — Linezolid / IV methylene blue; CYP3A4 inhibitors and inducers

Venlafaxine

Same body system: Psychiatry

Mechanism: Thought to potentiate serotonin and norepinephrine in the CNS by inhibiting their reuptake.

On both cards: Common side effects — Nausea · Interactions — MAO inhibitors

Only on the Venlafaxine card: Used for — Major depressive disorder in adults; Generalized anxiety disorder in adults; Social anxiety disorder in adults; Panic disorder in adults · Common side effects — Somnolence; Dry mouth; Sweating; Abnormal ejaculation · Warnings — Serotonin syndrome; Elevated blood pressure; Discontinuation syndrome · Interactions — Other serotonergic drugs; Antiplatelets / anticoagulants

Lorazepam

Same body system: Psychiatry

Mechanism: Binds the benzodiazepine site of GABA-A receptors in the brain, enhancing GABA-mediated synaptic inhibition.

On both cards: Warnings — CNS depression · Interactions — Alcohol / CNS depressants

Only on the Lorazepam card: Used for — Anxiety disorders in adults already receiving stable, evenly divided three-times-daily lorazepam tablets, when converted to the selected LOREEV XR formulation · Common side effects — Sedation; Dizziness; Weakness; Unsteadiness · Warnings — Contraindicated in acute narrow-angle glaucoma; Neonatal sedation and withdrawal · Interactions — Opioids; UGT inhibitors

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.