CapseraProton pump inhibitors
Compare the named medicines in this source-linked class directory.
Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.
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Generic names and pronunciation
Shared name ending: -prazole · Omeprazole, Pantoprazole, Esomeprazole magnesium
| Omeprazole · oh-MEP-ra-zole |
| Pantoprazole · pan-TOE-pra-zole |
| Esomeprazole magnesium · es-oh-MEP-ra-zole |
Pronunciation is shown for the US English generic name. A name ending is a memory cue, not a classification rule.
Body system and related classes
Body system: GI
How each medicine works
| Omeprazole — Substituted benzimidazole that inhibits the H+/K+ ATPase (proton pump) of the gastric parietal cell, blocking the final step of acid secretion. |
| Pantoprazole — Covalently binds the H+/K+ ATPase of the gastric parietal cell, suppressing the final step of acid production, basal and stimulated. |
| Esomeprazole magnesium — Converted in the parietal cell to an active inhibitor that blocks the H+/K+ ATPase (proton pump), suppressing gastric acid secretion. |
Each summary is the mechanism line from the medicine’s study card.
What each medicine is used for
| Omeprazole — Short-term treatment of active duodenal or benign gastric ulcer in adults; H. pylori eradication with the specified antibiotics in adults with duodenal ulcer disease; Short-term symptomatic GERD or erosive esophagitis treatment, and maintenance of healed erosive esophagitis, in patients aged 2 years and older; Long-term treatment of pathological hypersecretory conditions in adults |
| Pantoprazole — Short-term healing and symptom relief of GERD-associated erosive esophagitis in adults and children aged 5 years and older; Maintenance of healed erosive esophagitis and reduction of heartburn relapse in adults with GERD; Long-term treatment of pathological hypersecretory conditions, including Zollinger-Ellison syndrome, in adults |
| Esomeprazole magnesium — Short-term erosive-esophagitis healing in adults and ages 12–17; maintenance of healing in adults; Short-term heartburn and other GERD symptoms in adults and ages 12–17; Reduce NSAID-associated gastric-ulcer risk in adults receiving continuous NSAIDs who are aged 60 or older and/or have a documented gastric-ulcer history; With amoxicillin and clarithromycin, eradicate H. pylori in adults with active duodenal ulcer or a history within 5 years to reduce recurrence |
Each list is the uses line from the medicine’s study card.
Telling these medicines apart
Medicines in this class: 3
Listed on more than one card in this class
Common side effects
Headache · 3/3: Omeprazole, Pantoprazole, Esomeprazole magnesium
Abdominal pain · 3/3: Omeprazole, Pantoprazole, Esomeprazole magnesium
Nausea · 3/3: Omeprazole, Pantoprazole, Esomeprazole magnesium
Diarrhea · 3/3: Omeprazole, Pantoprazole, Esomeprazole magnesium
Flatulence · 2/3: Omeprazole, Esomeprazole magnesium
Warnings
C. difficile-associated diarrhea · 3/3: Omeprazole, Pantoprazole, Esomeprazole magnesium
Bone fracture with long-term use · 3/3: Omeprazole, Pantoprazole, Esomeprazole magnesium
Acute tubulointerstitial nephritis · 2/3: Omeprazole, Esomeprazole magnesium
Interactions
Clopidogrel · 2/3: Omeprazole, Esomeprazole magnesium
Warfarin · 2/3: Omeprazole, Pantoprazole
Listed on only one card in this class
Omeprazole: Interactions — Rilpivirine, atazanavir, nelfinavir
Pantoprazole: Warnings — Vitamin B12 deficiency · Interactions — Rilpivirine-containing antiretrovirals; Methotrexate
Esomeprazole magnesium: Interactions — Some antiretrovirals (e.g., rilpivirine)
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.