Nitroglycerin (sublingual): study card

Nitroglycerin (sublingual) — Nitrate vasodilator. Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Nitroglycerin (sublingual)
Class
Nitrate vasodilator
Mechanism
Releases nitric oxide, activating guanylate cyclase; rising cGMP dephosphorylates myosin light chains, relaxing vascular smooth muscle.
Used for
Acute relief or acute prophylaxis of angina pectoris due to coronary artery disease, for the cited sublingual tablets
Common side effects
Headache; Dizziness; Paresthesia; Flushing
Warnings
Severe hypotension; Tolerance with excessive use; Contraindicated with PDE-5 inhibitors
Interactions
PDE-5 inhibitors (e.g., sildenafil, tadalafil); sGC stimulators; Ergotamine

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260909 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Nitroglycerin (sublingual): nye-troe-GLI-ser-in

Pronunciation is shown for the US English generic name.

Body system

Cardiovascular · 47 Drug cards

Compare with related cards

Lisinopril

Same body system: Cardiovascular

Mechanism: Inhibits angiotensin-converting enzyme, blocking conversion of angiotensin I to angiotensin II and suppressing the renin-angiotensin-aldosterone system.

On both cards: Common side effects — Headache; Dizziness

Only on the Lisinopril card: Used for — Hypertension in adults and children aged 6 years and older; Adjunctive therapy for heart failure; Reduction of mortality after acute myocardial infarction in hemodynamically stable patients treated within 24 hours · Common side effects — Cough; Hypotension; Chest pain · Warnings — Angioedema; Hyperkalemia; Renal impairment · Interactions — Diuretics; NSAIDs; Lithium

Amlodipine

Same body system: Cardiovascular

Mechanism: Dihydropyridine calcium antagonist that inhibits transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle.

On both cards: Common side effects — Dizziness; Flushing

Only on the Amlodipine card: Used for — Hypertension; Symptomatic treatment of chronic stable angina; Confirmed or suspected vasospastic angina; Reduction of angina hospitalization or coronary revascularization risk in patients with recently angiographically documented coronary artery disease, without heart failure or an ejection fraction below 40% · Common side effects — Edema; Palpitations · Warnings — Symptomatic hypotension; Worsening angina or acute MI; Severe hepatic impairment · Interactions — CYP3A inhibitors; Simvastatin; Cyclosporine, tacrolimus

Spironolactone

Same body system: Cardiovascular

Mechanism: Competitively blocks aldosterone receptors in the distal tubule: more sodium and water excreted, potassium retained.

On both cards: Common side effects — Headache; Dizziness

Only on the Spironolactone card: Used for — Heart failure with reduced ejection fraction, NYHA class III–IV; Add-on treatment for hypertension inadequately controlled by other agents; Edema in adults with cirrhosis or nephrotic syndrome when the specified underlying-disease, fluid/sodium and other-diuretic measures are insufficient; Primary hyperaldosteronism: short-term before surgery or long-term in the selected nonsurgical/adrenal-hyperplasia settings · Common side effects — Hyperkalemia; Gynecomastia; Nausea / vomiting · Warnings — Hyperkalemia; Hypotension and worsening renal function; Contraindicated in Addison's disease · Interactions — ACE inhibitors / ARBs / potassium supplements; Lithium; NSAIDs

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.