Diltiazem: study card

Diltiazem — Calcium channel blocker. Study the mechanism, listed uses and warnings from the US label on one sourced card.

Generic name
Diltiazem
Class
Calcium channel blocker
Mechanism
Therapeutic effects are believed to relate to inhibition of calcium influx in cardiac and vascular smooth muscle; vascular relaxation lowers peripheral resistance and blood pressure.
Used for
Hypertension; Chronic stable angina
Common side effects
Rhinitis; Pharyngitis; Constipation; Peripheral edema; Myalgia
Warnings
Sick sinus syndrome is contraindicated unless a functioning ventricular pacemaker is present; Second- or third-degree AV block is contraindicated unless a functioning ventricular pacemaker is present; Systolic blood pressure below 90 mmHg is a contraindication
Interactions
Beta-blockers; Digitalis; CYP3A4 substrates

Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.

Read the source label ↗

Label date: 20260805 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.

Pronunciation

Diltiazem: dil-TYE-a-zem

Pronunciation is shown for the US English generic name.

Body system

Cardiovascular · 47 Drug cards

Compare with related cards

Verapamil

Same class on both cards

Mechanism: Lowers blood pressure by decreasing systemic vascular resistance, usually without reflex tachycardia.

On both cards: Common side effects — Constipation

Only on the Verapamil card: Used for — Hypertension in adults, for the cited extended-release tablets · Common side effects — Dizziness; Nausea; Hypotension; Headache · Warnings — Contraindicated with severe left ventricular dysfunction; Contraindicated with systolic blood pressure below 90 mmHg or cardiogenic shock; Sick sinus syndrome or second/third-degree AV block is contraindicated unless a functioning artificial ventricular pacemaker is present · Interactions — CYP3A4 inhibitors (erythromycin, ritonavir); CYP3A4 inducers (rifampin); HMG-CoA reductase inhibitors

Rosuvastatin

Same body system: Cardiovascular

Mechanism: Inhibits HMG-CoA reductase, the rate-limiting enzyme converting HMG-CoA to mevalonate, a precursor of cholesterol.

On both cards: Common side effects — Constipation; Myalgia

Only on the Rosuvastatin card: Used for — As an adjunct to diet to lower LDL cholesterol in adults with primary hyperlipidemia and to slow atherosclerosis progression in adults; Reduction of major cardiovascular events in adults without established coronary disease who meet the label's age, hsCRP of at least 2 mg/L and additional-risk-factor criteria; Heterozygous familial hypercholesterolemia in adults and children aged 8 years and older, as an adjunct to diet; Homozygous familial hypercholesterolemia in adults and children aged 7 years and older, with other LDL-lowering treatment or alone when unavailable · Common side effects — Headache; Nausea; Asthenia · Warnings — Myopathy / rhabdomyolysis; Immune-mediated necrotizing myopathy; Acute liver failure or decompensated cirrhosis · Interactions — Cyclosporine, gemfibrozil; Aluminum/magnesium hydroxide antacids; Warfarin

Clonidine

Same body system: Cardiovascular

Mechanism: Stimulates alpha-adrenoreceptors in the brain stem, reducing sympathetic outflow, peripheral resistance, heart rate and blood pressure.

On both cards: Used for — Hypertension · Common side effects — Constipation

Only on the Clonidine card: Common side effects — Dry mouth; Drowsiness; Dizziness · Warnings — Rebound hypertension if stopped suddenly; Bradycardia and AV block; Sedation · Interactions — Alcohol and CNS depressants; Tricyclic antidepressants; Beta-blockers, digitalis, CCBs

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.