Antimuscarinic bladder medicines

Compare the named medicines in this source-linked class directory.

Membership describes a named action or a component of a combination. A medicine may appear in several families. Medicines in one family are not automatically interchangeable; this is a study directory, not a prescribing guide.

Oxybutynin
Solifenacin

Generic names and pronunciation

Oxybutynin · ox-i-BYOO-ti-nin
Solifenacin · sol-i-FEN-a-sin

Pronunciation is shown for the US English generic name.

Body system and related classes

Body system: Genitourinary

How each medicine works

Oxybutynin — Relaxes bladder smooth muscle by a direct antispasmodic effect and by inhibiting the muscarinic action of acetylcholine.
Solifenacin — Competitive muscarinic receptor antagonist; muscarinic receptors mediate cholinergic bladder smooth muscle contraction.

Each summary is the mechanism line from the medicine’s study card.

What each medicine is used for

Oxybutynin — Overactive bladder with urge urinary incontinence, urgency and frequency; Symptoms of detrusor overactivity associated with a neurological condition in children aged 6 or older
Solifenacin — Overactive bladder with urgency, urinary frequency or urge urinary incontinence in adults

Each list is the uses line from the medicine’s study card.

Telling these medicines apart

Medicines in this class: 2

Listed on more than one card in this class

Common side effects

Dry mouth · 2/2: Oxybutynin, Solifenacin

Constipation · 2/2: Oxybutynin, Solifenacin

Listed on only one card in this class

Oxybutynin: Common side effects — Diarrhea; Headache; Somnolence · Warnings — Urinary retention, gastric retention or severe decreased gastrointestinal motility; uncontrolled narrow-angle glaucoma are contraindications; Angioedema; Anticholinergic CNS effects · Interactions — Other anticholinergic drugs; Prokinetic agents (metoclopramide)

Solifenacin: Common side effects — Urinary tract infection; Blurred vision · Warnings — Angioedema and anaphylaxis; Urinary retention (outlet obstruction); QT prolongation in high-risk patients · Interactions — Strong CYP3A4 inhibitors (e.g., ketoconazole)

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.