Dermatology

Triamcinolone — Topical corticosteroid with anti-inflammatory, antipruritic and vasoconstrictive actions; exact anti-inflammatory mechanism is unclear.

Clobetasol Propionate — Anti-inflammatory, antipruritic, vasoconstrictive; thought to induce lipocortins that inhibit phospholipase A2 and arachidonic acid release.

Mupirocin — Interrupts bacterial protein synthesis by binding reversibly to bacterial isoleucyl-tRNA synthetase.

Ketoconazole — Mechanism in seborrheic dermatitis is not known.

Hydrocortisone Butyrate — Corticosteroid acting on cell signaling, immune function and inflammation; precise mechanism in atopic dermatitis unknown.

Tretinoin — Activates retinoic acid receptors (RAR-alpha, beta, gamma) that may modify epithelial cell growth and differentiation.

Clindamycin — Mechanism in treating acne vulgaris is unknown.

Nystatin (topical powder) — A polyene antibiotic with fungistatic and fungicidal activity in vitro against susceptible yeasts, including Candida. It is not absorbed from intact skin or mucous membranes.

Fluorouracil (topical cream) — Blocks methylation of deoxyuridylic acid to thymidylic acid, interfering with DNA and, less so, RNA synthesis.

Chlorhexidine gluconate — Topical antiseptic cleanser that helps reduce bacteria that potentially can cause disease.

Clotrimazole / Betamethasone Dipropionate — Clotrimazole is an azole antifungal; betamethasone dipropionate is a corticosteroid.

Metronidazole — Nitroimidazole compound; its mechanism in treating rosacea is unknown.

Clotrimazole — Broad-spectrum antifungal acting primarily on dividing and growing organisms; fungistatic and fungicidal activity is demonstrated in vitro against specified susceptible fungi.

Betamethasone Dipropionate — Corticosteroid acting on cell signaling, immune function and inflammation; exact mechanism in dermatoses unknown.

Ciclopirox — Chelates polyvalent cations such as Fe3+ or Al3+, inhibiting fungal metal-dependent enzymes that degrade peroxides. The relevance of its antifungal property to seborrheic dermatitis is unknown.

Hydroquinone — The selected 4% hydroquinone product describes inhibition of melanin production; its brief label does not explain a detailed molecular mechanism.

Mometasone Furoate — Corticosteroid acting on cell signaling, immune function, and inflammation; precise mechanism in dermatoses unknown.

Ammonium Lactate — Lactic acid is an alpha-hydroxy acid thought to act as a humectant and may influence stratum-corneum hydration and reduce corneocyte cohesion; the mechanism is not yet known.

Each summary is the mechanism line from the medicine’s study card.

Listed most often on cards in this body system

Common side effects

Burning · 5/18: Triamcinolone, Clindamycin, Nystatin (topical powder), Ciclopirox, Mometasone Furoate (topical)

Itching · 5/18: Triamcinolone, Mupirocin, Clindamycin, Nystatin (topical powder), Ammonium Lactate

Pruritus · 5/18: Clobetasol Propionate, Fluorouracil (topical cream), Clotrimazole, Ciclopirox, Mometasone Furoate (topical)

Erythema · 5/18: Tretinoin, Clindamycin, Fluorouracil (topical cream), Clotrimazole, Ciclopirox

Dryness · 3/18: Triamcinolone, Tretinoin, Clindamycin

Skin atrophy · 3/18: Clobetasol Propionate, Betamethasone Dipropionate, Mometasone Furoate (topical)

Warnings

HPA axis suppression · 3/18: Clobetasol Propionate, Hydrocortisone Butyrate, Betamethasone Dipropionate

Cataracts and glaucoma · 3/18: Hydrocortisone Butyrate, Betamethasone Dipropionate, Mometasone Furoate (topical)

An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.