Class I antiarrhythmics; Other local anesthetics; Drugs linked to methemoglobinemia
Brand questions use only name pairings verified against the linked product source. Unverified pairings are withheld from these questions; the other study content remains available.
Label date: 20251006 · For learning, not clinical decisions. US label and brand information; always consult the current source.
Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.
Mechanism: The mechanism is not completely understood but involves inhibition of COX-1 and COX-2. Diclofenac inhibits prostaglandin synthesis in vitro; reduced peripheral prostaglandins may contribute to its analgesic and anti-inflammatory effects.
On both cards: Common side effects — Erythema; Pruritus
Only on the Diclofenac (topical) card: Used for — Pain of osteoarthritis of the knee · Common side effects — Application site dryness; Exfoliation · Warnings — Hepatotoxicity; Heart failure and edema; Renal toxicity · Interactions — Anticoagulants (warfarin); Drugs interfering with hemostasis (SSRIs)
An item counts as shared only when both cards use the same wording. If a card does not list an item, that is not a statement that the effect never occurs.