Evolocumab: brand names and study card

Generic name

Evolocumab

Brands

Repatha

Class

PCSK9 inhibitor (monoclonal antibody)

Mechanism

Human IgG2 antibody against PCSK9; blocks PCSK9 binding to LDL receptors, leaving more receptors to clear LDL-C.

Used for

Reduction of major adverse cardiovascular events in adults at increased risk; As an adjunct to diet and exercise to lower LDL cholesterol in adults with hypercholesterolemia; As an adjunct to diet and exercise to lower LDL cholesterol in adults and children aged 10 years and older with heterozygous familial hypercholesterolemia; As an adjunct to diet and exercise to lower LDL cholesterol in adults and children aged 10 years and older with homozygous familial hypercholesterolemia

Common side effects

Nasopharyngitis; Upper respiratory tract infection; Influenza; Back pain; Injection site reactions

Warnings

Hypersensitivity reactions incl. angioedema; Latex in some needle covers

Label date: 20260819 · For learning, not clinical decisions. US label and brand information; always consult the current source.

Source snapshot checked: 2026-10-21. The source document and selected fields were compared. The complete card has not had an independent clinical review.